| 8/28/2025 | Boise State | at | South Florida | MW | ||||
| 9/6/2025 | South Florida | at | Florida | at SEC | ||||
| 9/13/2025 | South Florida | at | Miami-Florida | at ACC | ||||
| 9/20/2025 | South Carolina State | at | South Florida | MEAC (1AA) | ||||
| 10/3/2025 | UNC-Charlotte | at | South Florida | |||||
| 10/10/2025 | South Florida | at | North Texas | |||||
| 10/18/2025 | Florida Atlantic | at | South Florida | |||||
| 10/25/2025 | South Florida | at | Memphis | |||||
| 11/6/2025 | Texas-San Antonio | at | South Florida | |||||
| 11/15/2025 | South Florida | at | Navy | |||||
| 11/22/2025 | South Florida | at | UAB | |||||
| 11/29/2025 | Rice | at | South Florida |