| 8/31/2025 | Virginia Tech | vs | South Carolina | Atlanta GA | ACC | |||
| 9/6/2025 | South Carolina State | at | South Carolina | MEAC (1AA) | ||||
| 9/13/2025 | Vanderbilt | at | South Carolina | |||||
| 9/20/2025 | South Carolina | at | Missouri | |||||
| 9/27/2025 | Kentucky | at | South Carolina | |||||
| 10/11/2025 | South Carolina | at | LSU | |||||
| 10/18/2025 | Oklahoma | at | South Carolina | |||||
| 10/25/2025 | Alabama | at | South Carolina | |||||
| 11/1/2025 | South Carolina | at | Mississippi | |||||
| 11/15/2025 | South Carolina | at | Texas A&M | |||||
| 11/22/2025 | Coastal Carolina | at | South Carolina | SBC | ||||
| 11/29/2025 | Clemson | at | South Carolina | ACC |