| 8/30/2025 | East Texas A&M | at | SMU | SLC (1AA) | ||||
| 9/6/2025 | Baylor | at | SMU | B12 | ||||
| 9/13/2025 | SMU | at | Missouri State | at CUSA | ||||
| 9/20/2025 | SMU | at | TCU | at B12 | ||||
| 10/4/2025 | Syracuse | at | SMU | |||||
| 10/11/2025 | Stanford | at | SMU | |||||
| 10/18/2025 | SMU | at | Clemson | |||||
| 10/25/2025 | SMU | at | Wake Forest | |||||
| 11/1/2025 | Miami-Florida | at | SMU | |||||
| 11/8/2025 | SMU | at | Boston College | |||||
| 11/22/2025 | Louisville | at | SMU | |||||
| 11/29/2025 | SMU | at | California |