| 8/30/2025 | Ball State | at | Purdue | MAC | ||||
| 9/6/2025 | Southern Illinois | at | Purdue | MVC (1AA) | ||||
| 9/13/2025 | Southern California | at | Purdue | |||||
| 9/20/2025 | Purdue | at | Notre Dame | at ND | ||||
| 10/4/2025 | Illinois | at | Purdue | |||||
| 10/11/2025 | Purdue | at | Minnesota | |||||
| 10/18/2025 | Purdue | at | Northwestern | |||||
| 10/25/2025 | Rutgers | at | Purdue | |||||
| 11/1/2025 | Purdue | at | Michigan | |||||
| 11/8/2025 | Ohio State | at | Purdue | |||||
| 11/15/2025 | Purdue | at | Washington | |||||
| 11/28/2025 | Indiana | at | Purdue |