| 8/30/2025 | Duquesne | at | Pittsburgh | NE (1AA) | ||||
| 9/6/2025 | Central Michigan | at | Pittsburgh | MAC | ||||
| 9/13/2025 | Pittsburgh | at | West Virginia | at B12 | ||||
| 9/27/2025 | Louisville | at | Pittsburgh | |||||
| 10/4/2025 | Boston College | at | Pittsburgh | |||||
| 10/11/2025 | Pittsburgh | at | Florida State | |||||
| 10/18/2025 | Pittsburgh | at | Syracuse | |||||
| 10/25/2025 | North Carolina State | at | Pittsburgh | |||||
| 11/1/2025 | Pittsburgh | at | Stanford | |||||
| 11/15/2025 | Notre Dame | at | Pittsburgh | ND | ||||
| 11/22/2025 | Pittsburgh | at | Georgia Tech | |||||
| 11/29/2025 | Miami-Florida | at | Pittsburgh |