| 8/30/2025 | Nevada | at | Penn State | MW | ||||
| 9/6/2025 | Florida Intl | at | Penn State | CUSA | ||||
| 9/13/2025 | Villanova | at | Penn State | CAAF (1AA) | ||||
| 9/27/2025 | Oregon | at | Penn State | |||||
| 10/4/2025 | Penn State | at | UCLA | |||||
| 10/11/2025 | Northwestern | at | Penn State | |||||
| 10/18/2025 | Penn State | at | Iowa | |||||
| 11/1/2025 | Penn State | at | Ohio State | |||||
| 11/8/2025 | Indiana | at | Penn State | |||||
| 11/15/2025 | Penn State | at | Michigan State | |||||
| 11/22/2025 | Nebraska | at | Penn State | |||||
| 11/29/2025 | Penn State | at | Rutgers |