| 8/30/2025 | Old Dominion | at | Indiana | at B10 | ||||
| 9/6/2025 | North Carolina Central | at | Old Dominion | MEAC (1AA) | ||||
| 9/13/2025 | Old Dominion | at | Virginia Tech | at ACC | ||||
| 9/27/2025 | Liberty | at | Old Dominion | CUSA | ||||
| 10/4/2025 | Coastal Carolina | at | Old Dominion | |||||
| 10/11/2025 | Old Dominion | at | Marshall | |||||
| 10/18/2025 | Old Dominion | at | James Madison | |||||
| 10/25/2025 | Appalachian State | at | Old Dominion | |||||
| 11/1/2025 | Old Dominion | at | UL Monroe | |||||
| 11/13/2025 | Troy | at | Old Dominion | |||||
| 11/22/2025 | Old Dominion | at | Georgia Southern | |||||
| 11/29/2025 | Georgia State | at | Old Dominion |