| 8/30/2025 | Illinois State | at | Oklahoma | MVC (1AA) | ||||
| 9/6/2025 | Michigan | at | Oklahoma | B10 | ||||
| 9/13/2025 | Oklahoma | at | Temple | at AAC | ||||
| 9/20/2025 | Auburn | at | Oklahoma | |||||
| 10/4/2025 | Kent State | at | Oklahoma | MAC | ||||
| 10/11/2025 | Oklahoma | vs | Texas | Dallas TX | ||||
| 10/18/2025 | Oklahoma | at | South Carolina | |||||
| 10/25/2025 | Mississippi | at | Oklahoma | |||||
| 11/1/2025 | Oklahoma | at | Tennessee | |||||
| 11/15/2025 | Oklahoma | at | Alabama | |||||
| 11/22/2025 | Missouri | at | Oklahoma | |||||
| 11/29/2025 | LSU | at | Oklahoma |