| 8/30/2025 | Texas | at | Ohio State | SEC | ||||
| 9/6/2025 | Grambling | at | Ohio State | SWAC (1AA) | ||||
| 9/13/2025 | Ohio | at | Ohio State | MAC | ||||
| 9/27/2025 | Ohio State | at | Washington | |||||
| 10/4/2025 | Minnesota | at | Ohio State | |||||
| 10/11/2025 | Ohio State | at | Illinois | |||||
| 10/18/2025 | Ohio State | at | Wisconsin | |||||
| 11/1/2025 | Penn State | at | Ohio State | |||||
| 11/8/2025 | Ohio State | at | Purdue | |||||
| 11/15/2025 | UCLA | at | Ohio State | |||||
| 11/22/2025 | Rutgers | at | Ohio State | |||||
| 11/29/2025 | Ohio State | at | Michigan |