| 8/31/2025 | Notre Dame | at | Miami-Florida | at ACC | ||||
| 9/13/2025 | Texas A&M | at | Notre Dame | SEC | ||||
| 9/20/2025 | Purdue | at | Notre Dame | B10 | ||||
| 9/27/2025 | Notre Dame | at | Arkansas | at SEC | ||||
| 10/4/2025 | Boise State | at | Notre Dame | MW | ||||
| 10/11/2025 | North Carolina State | at | Notre Dame | ACC | ||||
| 10/18/2025 | Southern California | at | Notre Dame | B10 | ||||
| 11/1/2025 | Notre Dame | at | Boston College | at ACC | ||||
| 11/8/2025 | Navy | at | Notre Dame | AAC | ||||
| 11/15/2025 | Notre Dame | at | Pittsburgh | at ACC | ||||
| 11/22/2025 | Syracuse | at | Notre Dame | ACC | ||||
| 11/29/2025 | Notre Dame | at | Stanford | at ACC |