| 8/30/2025 | Temple | at | Massachusetts | AAC | ||||
| 9/6/2025 | Bryant | at | Massachusetts | CAAF (1AA) | ||||
| 9/13/2025 | Massachusetts | at | Iowa | at B10 | ||||
| 9/27/2025 | Massachusetts | at | Missouri | at SEC | ||||
| 10/4/2025 | Western Michigan | at | Massachusetts | |||||
| 10/11/2025 | Massachusetts | at | Kent State | |||||
| 10/18/2025 | Buffalo | at | Massachusetts | |||||
| 10/25/2025 | Massachusetts | at | Central Michigan | |||||
| 11/4/2025 | Massachusetts | at | Akron | |||||
| 11/12/2025 | Northern Illinois | at | Massachusetts | |||||
| 11/18/2025 | Massachusetts | at | Ohio | |||||
| 11/25/2025 | Bowling Green | at | Massachusetts |