| 8/30/2025 | Eastern Kentucky | at | Louisville | UAC (1AA) | ||||
| 9/5/2025 | James Madison | at | Louisville | SBC | ||||
| 9/20/2025 | Bowling Green | at | Louisville | MAC | ||||
| 9/27/2025 | Louisville | at | Pittsburgh | |||||
| 10/4/2025 | Virginia | at | Louisville | |||||
| 10/17/2025 | Louisville | at | Miami-Florida | |||||
| 10/25/2025 | Boston College | at | Louisville | |||||
| 11/1/2025 | Louisville | at | Virginia Tech | |||||
| 11/8/2025 | California | at | Louisville | |||||
| 11/14/2025 | Clemson | at | Louisville | |||||
| 11/22/2025 | Louisville | at | SMU | |||||
| 11/29/2025 | Kentucky | at | Louisville | SEC |