| 8/23/2025 | Kansas State | vs | Iowa State | Dublin IE | ||||
| 8/30/2025 | South Dakota | at | Iowa State | MVC (1AA) | ||||
| 9/6/2025 | Iowa | at | Iowa State | B10 | ||||
| 9/13/2025 | Iowa State | at | Arkansas State | at SBC | ||||
| 9/27/2025 | Arizona | at | Iowa State | |||||
| 10/4/2025 | Iowa State | at | Cincinnati | |||||
| 10/11/2025 | Iowa State | at | Colorado | |||||
| 10/25/2025 | BYU | at | Iowa State | |||||
| 11/1/2025 | Arizona State | at | Iowa State | |||||
| 11/8/2025 | Iowa State | at | TCU | |||||
| 11/22/2025 | Kansas | at | Iowa State | |||||
| 11/29/2025 | Iowa State | at | Oklahoma State |