| 8/30/2025 | Albany NY | at | Iowa | CAAF (1AA) | ||||
| 9/6/2025 | Iowa | at | Iowa State | at B12 | ||||
| 9/13/2025 | Massachusetts | at | Iowa | MAC | ||||
| 9/19/2025 | Iowa | at | Rutgers | |||||
| 9/27/2025 | Indiana | at | Iowa | |||||
| 10/11/2025 | Iowa | at | Wisconsin | |||||
| 10/18/2025 | Penn State | at | Iowa | |||||
| 10/25/2025 | Minnesota | at | Iowa | |||||
| 11/8/2025 | Oregon | at | Iowa | |||||
| 11/15/2025 | Iowa | at | Southern California | |||||
| 11/22/2025 | Michigan State | at | Iowa | |||||
| 11/28/2025 | Iowa | at | Nebraska |