| 8/28/2025 | East Carolina | at | North Carolina State | at ACC | ||||
| 9/6/2025 | Campbell | at | East Carolina | CAAF (1AA) | ||||
| 9/13/2025 | East Carolina | at | Coastal Carolina | at SBC | ||||
| 9/20/2025 | BYU | at | East Carolina | B12 | ||||
| 9/25/2025 | Army | at | East Carolina | |||||
| 10/9/2025 | East Carolina | at | Tulane | |||||
| 10/16/2025 | Tulsa | at | East Carolina | |||||
| 11/1/2025 | East Carolina | at | Temple | |||||
| 11/8/2025 | UNC-Charlotte | at | East Carolina | |||||
| 11/15/2025 | Memphis | at | East Carolina | |||||
| 11/22/2025 | East Carolina | at | Texas-San Antonio | |||||
| 11/29/2025 | East Carolina | at | Florida Atlantic |