| 8/28/2025 | Elon | at | Duke | CAAF (1AA) | ||||
| 9/6/2025 | Illinois | at | Duke | B10 | ||||
| 9/13/2025 | Duke | at | Tulane | at AAC | ||||
| 9/20/2025 | North Carolina State | at | Duke | |||||
| 9/27/2025 | Duke | at | Syracuse | |||||
| 10/4/2025 | Duke | at | California | |||||
| 10/18/2025 | Georgia Tech | at | Duke | |||||
| 11/1/2025 | Duke | at | Clemson | |||||
| 11/8/2025 | Duke | at | Connecticut | at Ind | ||||
| 11/15/2025 | Virginia | at | Duke | |||||
| 11/22/2025 | Duke | at | North Carolina | |||||
| 11/29/2025 | Wake Forest | at | Duke |