| 8/30/2025 | LSU | at | Clemson | SEC | ||||
| 9/6/2025 | Troy | at | Clemson | SBC | ||||
| 9/13/2025 | Clemson | at | Georgia Tech | |||||
| 9/20/2025 | Syracuse | at | Clemson | |||||
| 10/4/2025 | Clemson | at | North Carolina | |||||
| 10/11/2025 | Clemson | at | Boston College | |||||
| 10/18/2025 | SMU | at | Clemson | |||||
| 11/1/2025 | Duke | at | Clemson | |||||
| 11/8/2025 | Florida State | at | Clemson | |||||
| 11/14/2025 | Clemson | at | Louisville | |||||
| 11/22/2025 | Furman | at | Clemson | SoCon (1AA) | ||||
| 11/29/2025 | Clemson | at | South Carolina | at SEC |