| 8/28/2025 | Cincinnati | vs | Nebraska | Kansas City MO | vs B10 | |||
| 9/6/2025 | Bowling Green | at | Cincinnati | MAC | ||||
| 9/13/2025 | Northwestern State | at | Cincinnati | SLC (1AA) | ||||
| 9/27/2025 | Cincinnati | at | Kansas | |||||
| 10/4/2025 | Iowa State | at | Cincinnati | |||||
| 10/11/2025 | UCF | at | Cincinnati | |||||
| 10/18/2025 | Cincinnati | at | Oklahoma State | |||||
| 10/25/2025 | Baylor | at | Cincinnati | |||||
| 11/1/2025 | Cincinnati | at | Utah | |||||
| 11/15/2025 | Arizona | at | Cincinnati | |||||
| 11/22/2025 | BYU | at | Cincinnati | |||||
| 11/29/2025 | Cincinnati | at | TCU |