| 8/28/2025 | Buffalo | at | Minnesota | at B10 | ||||
| 9/6/2025 | St Francis PA | at | Buffalo | NE (1AA) | ||||
| 9/13/2025 | Buffalo | at | Kent State | |||||
| 9/20/2025 | Troy | at | Buffalo | SBC | ||||
| 9/27/2025 | Connecticut | at | Buffalo | Ind | ||||
| 10/4/2025 | Eastern Michigan | at | Buffalo | |||||
| 10/18/2025 | Buffalo | at | Massachusetts | |||||
| 10/25/2025 | Akron | at | Buffalo | |||||
| 11/1/2025 | Buffalo | at | Bowling Green | |||||
| 11/12/2025 | Buffalo | at | Central Michigan | |||||
| 11/19/2025 | Miami-Ohio | at | Buffalo | |||||
| 11/28/2025 | Ohio | at | Buffalo |