| 8/28/2025 | Wyoming | at | Akron | MW | ||||
| Lafayette | at | Bowling Green | Pat (1AA) | |||||
| Buffalo | at | Minnesota | @ B10 | |||||
| Ohio | at | Rutgers | @ B10 | |||||
| Miami-Ohio | at | Wisconsin | @ B10 | |||||
| 8/29/2025 | Western Michigan | at | Michigan State | @ B10 | ||||
| Central Michigan | at | San Jose State | @ MW | |||||
| 8/30/2025 | Merrimack | at | Kent State | Ind1AA (1AA) | ||||
| Toledo | at | Kentucky | @ SEC | |||||
| Temple | at | Massachusetts | AAC | |||||
| Holy Cross | at | Northern Illinois | Pat (1AA) | |||||
| Ball State | at | Purdue | @ B10 | |||||
| Eastern Michigan | at | Texas State | @ SBC | |||||
| 9/5/2025 | Northern Illinois | at | Maryland | @ B10 | ||||
| 9/6/2025 | Ball State | at | Auburn | @ SEC | ||||
| St Francis PA | at | Buffalo | NE (1AA) | |||||
| Bowling Green | at | Cincinnati | @ B12 | |||||
| LIU | at | Eastern Michigan | NE (1AA) | |||||
| Bryant | at | Massachusetts | CAAF (1AA) | |||||
| Akron | at | Nebraska | @ B10 | |||||
| West Virginia | at | Ohio | B12 | |||||
| Central Michigan | at | Pittsburgh | @ ACC | |||||
| Miami-Ohio | at | Rutgers | @ B10 | |||||
| Kent State | at | Texas Tech | @ B12 | |||||
| Western Kentucky | at | Toledo | CUSA | |||||
| North Texas | at | Western Michigan | AAC | |||||
| 9/13/2025 | Akron | at | UAB | @ AAC | ||||
| New Hampshire | at | Ball State | CAAF (1AA) | |||||
| Liberty | at | Bowling Green | CUSA | |||||
| Western Michigan | at | Illinois | @ B10 | |||||
| Massachusetts | at | Iowa | @ B10 | |||||
| Buffalo | at | Kent State | ||||||
| Eastern Michigan | at | Kentucky | @ SEC | |||||
| Central Michigan | at | Michigan | @ B10 | |||||
| Ohio | at | Ohio State | @ B10 | |||||
| Morgan State | at | Toledo | MEAC (1AA) | |||||
| 9/20/2025 | Duquesne | at | Akron | NE (1AA) | ||||
| Troy | at | Buffalo | SBC | |||||
| Wagner | at | Central Michigan | NE (1AA) | |||||
| Ball State | at | Connecticut | @ Ind | |||||
| UL Lafayette | at | Eastern Michigan | SBC | |||||
| Kent State | at | Florida State | @ ACC | |||||
| Bowling Green | at | Louisville | @ ACC | |||||
| UNLV | at | Miami-Ohio | MW | |||||
| Northern Illinois | at | Mississippi State | @ SEC | |||||
| Gardner-Webb | at | Ohio | BigS (1AA) | |||||
| Toledo | at | Western Michigan | ||||||
| 9/27/2025 | Connecticut | at | Buffalo | Ind | ||||
| Eastern Michigan | at | Central Michigan | ||||||
| Lindenwood | at | Miami-Ohio | BigS (1AA) | |||||
| Massachusetts | at | Missouri | @ SEC | |||||
| San Diego State | at | Northern Illinois | MW | |||||
| San Diego State | at | Northern Illinois | MW | |||||
| Bowling Green | at | Ohio | ||||||
| Akron | at | Toledo | ||||||
| Rhode Island | at | Western Michigan | CAAF (1AA) | |||||
| 10/4/2025 | Central Michigan | at | Akron | |||||
| Ohio | at | Ball State | ||||||
| Eastern Michigan | at | Buffalo | ||||||
| Western Michigan | at | Massachusetts | ||||||
| Miami-Ohio | at | Northern Illinois | ||||||
| Kent State | at | Oklahoma | @ SEC | |||||
| 10/11/2025 | Miami-Ohio | at | Akron | |||||
| Toledo | at | Bowling Green | ||||||
| Northern Illinois | at | Eastern Michigan | ||||||
| Massachusetts | at | Kent State | ||||||
| Ball State | at | Western Michigan | ||||||
| 10/18/2025 | Akron | at | Ball State | |||||
| Central Michigan | at | Bowling Green | ||||||
| Buffalo | at | Massachusetts | ||||||
| Eastern Michigan | at | Miami-Ohio | ||||||
| Northern Illinois | at | Ohio | ||||||
| Kent State | at | Toledo | ||||||
| 10/25/2025 | Akron | at | Buffalo | |||||
| Massachusetts | at | Central Michigan | ||||||
| Ohio | at | Eastern Michigan | ||||||
| Bowling Green | at | Kent State | ||||||
| Western Michigan | at | Miami-Ohio | ||||||
| Ball State | at | Northern Illinois | ||||||
| Toledo | at | Washington State | @ Ind | |||||
| 11/1/2025 | Buffalo | at | Bowling Green | |||||
| Central Michigan | at | Western Michigan | ||||||
| 11/4/2025 | Massachusetts | at | Akron | |||||
| Miami-Ohio | at | Ohio | ||||||
| 11/5/2025 | Kent State | at | Ball State | |||||
| Northern Illinois | at | Toledo | ||||||
| 11/8/2025 | Bowling Green | at | Eastern Michigan | |||||
| 11/11/2025 | Kent State | at | Akron | |||||
| Ohio | at | Western Michigan | ||||||
| 11/12/2025 | Buffalo | at | Central Michigan | |||||
| Northern Illinois | at | Massachusetts | ||||||
| Toledo | at | Miami-Ohio | ||||||
| 11/15/2025 | Eastern Michigan | at | Ball State | |||||
| 11/18/2025 | Akron | at | Bowling Green | |||||
| Western Michigan | at | Northern Illinois | ||||||
| Massachusetts | at | Ohio | ||||||
| 11/19/2025 | Miami-Ohio | at | Buffalo | |||||
| Central Michigan | at | Kent State | ||||||
| 11/22/2025 | Ball State | at | Toledo | |||||
| 11/25/2025 | Western Michigan | at | Eastern Michigan | |||||
| Bowling Green | at | Massachusetts | ||||||
| 11/28/2025 | Ohio | at | Buffalo | |||||
| Kent State | at | Northern Illinois | ||||||
| 11/29/2025 | Toledo | at | Central Michigan | |||||
| Ball State | at | Miami-Ohio |