| 8/28/2025 | West Liberty | at | Walsh | MtnE | ||||
| 8/30/2025 | Thomas More | at | Southern Illinois | @ MVC (1AA) | ||||
| 9/4/2025 | Ashland | at | Indiana PA | @ PSAC | ||||
| Tiffin | at | Wayne State MI | @ GLIAC | |||||
| 9/6/2025 | Thomas More | at | Dayton | @ Pio (1AA) | ||||
| Indianapolis | at | Findlay | GLV | |||||
| West Florida | at | Kentucky Wesleyan | GSC | |||||
| Ferris State | at | Lake Erie | GLIAC | |||||
| Hillsdale | at | McKendree | @ GLV | |||||
| Northern Michigan | at | Northwood | GLIAC | |||||
| Walsh | at | Wheeling | @ MtnE | |||||
| 9/11/2025 | Ohio Dominican | at | West Virginia Wesleyan | @ MtnE | ||||
| 9/13/2025 | Tiffin | at | Ferris State | @ GLIAC | ||||
| Wayne State MI | at | Findlay | GLIAC | |||||
| Michigan Tech | at | Hillsdale | GLIAC | |||||
| Ashland | at | Indianapolis | @ GLV | |||||
| Wheeling | at | Lake Erie | MtnE | |||||
| Northwood | at | Saginaw Valley State | @ GLIAC | |||||
| Kentucky Wesleyan | at | William Jewell | @ GLV | |||||
| 9/20/2025 | Hillsdale | at | Ashland | |||||
| Walsh | at | Kentucky Wesleyan | ||||||
| Findlay | at | Lake Erie | ||||||
| Thomas More | at | Northwood | ||||||
| Tiffin | at | Ohio Dominican | ||||||
| 9/27/2025 | Thomas More | at | Findlay | |||||
| Kentucky Wesleyan | at | Hillsdale | ||||||
| Tiffin | at | Lake Erie | ||||||
| Ashland | at | Northwood | ||||||
| Ohio Dominican | at | Walsh | ||||||
| 10/4/2025 | Ashland | at | Kentucky Wesleyan | |||||
| Northwood | at | Ohio Dominican | ||||||
| Lake Erie | at | Thomas More | ||||||
| Hillsdale | at | Tiffin | ||||||
| Findlay | at | Walsh | ||||||
| 10/11/2025 | Thomas More | at | Ashland | |||||
| Hillsdale | at | Findlay | ||||||
| Ohio Dominican | at | Kentucky Wesleyan | ||||||
| Lake Erie | at | Northwood | ||||||
| Walsh | at | Tiffin | ||||||
| 10/18/2025 | Kentucky Wesleyan | at | Findlay | |||||
| Northwood | at | Hillsdale | ||||||
| Walsh | at | Lake Erie | ||||||
| Ashland | at | Ohio Dominican | ||||||
| Tiffin | at | Thomas More | ||||||
| 10/25/2025 | Ohio Dominican | at | Findlay | |||||
| Lake Erie | at | Hillsdale | ||||||
| Northwood | at | Kentucky Wesleyan | ||||||
| Ashland | at | Tiffin | ||||||
| Thomas More | at | Walsh | ||||||
| 11/1/2025 | Walsh | at | Ashland | |||||
| Findlay | at | Northwood | ||||||
| Lake Erie | at | Ohio Dominican | ||||||
| Hillsdale | at | Thomas More | ||||||
| Kentucky Wesleyan | at | Tiffin | ||||||
| 11/8/2025 | Findlay | at | Ashland | |||||
| Kentucky Wesleyan | at | Lake Erie | ||||||
| Tiffin | at | Northwood | ||||||
| Ohio Dominican | at | Thomas More | ||||||
| Hillsdale | at | Walsh | ||||||
| 11/15/2025 | Lake Erie | at | Ashland | |||||
| Tiffin | at | Findlay | ||||||
| Ohio Dominican | at | Hillsdale | ||||||
| Thomas More | at | Kentucky Wesleyan | ||||||
| Northwood | at | Walsh |