| 8/28/2025 | Dayton | at | Eastern Illinois | Pio | ||||
| Tennessee-Martin | at | Oklahoma State | @ B12 (1A) | |||||
| Lindenwood | at | St Thomas | @ Pio | |||||
| 8/29/2025 | Western Illinois | at | Illinois | @ B10 (1A) | ||||
| 8/30/2025 | SE Missouri State | at | Arkansas State | @ SBC (1A) | ||||
| North Carolina A&T | at | Tennessee State | CAAF | |||||
| Cumberland TN | at | Tennessee Tech | MSC (NAIA) | |||||
| Charleston Southern | at | Vanderbilt | @ SEC (1A) | |||||
| Gardner-Webb | at | Western Carolina | @ SoCon | |||||
| 9/5/2025 | Western Illinois | at | Northwestern | @ B10 (1A) | ||||
| 9/6/2025 | Lindenwood | at | Appalachian State | @ SBC (1A) | ||||
| Charleston Southern | at | Coastal Carolina | @ SBC (1A) | |||||
| Gardner-Webb | at | Georgia Tech | @ ACC (1A) | |||||
| Eastern Illinois | at | Indiana State | @ MVC | |||||
| North Alabama | at | SE Missouri State | UAC | |||||
| North Dakota State | at | Tennessee State | MVC | |||||
| Chattanooga | at | Tennessee Tech | SoCon | |||||
| Tennessee-Martin | at | UTEP | @ CUSA (1A) | |||||
| 9/13/2025 | Lindenwood | at | Charleston Southern | |||||
| Illinois State | at | Eastern Illinois | MVC | |||||
| The Citadel | at | Gardner-Webb | SoCon | |||||
| SE Missouri State | at | North Dakota State | @ MVC | |||||
| Alabama A&M | at | Tennessee State | SWAC | |||||
| Davidson | at | Tennessee Tech | Pio | |||||
| Southern Illinois | at | Tennessee-Martin | MVC | |||||
| Valparaiso | at | Western Illinois | Pio | |||||
| 9/20/2025 | Western Illinois | at | Eastern Washington | @ BSky | ||||
| Stony Brook | at | Lindenwood | CAAF | |||||
| Tennessee-Martin | at | Missouri State | @ CUSA (1A) | |||||
| Gardner-Webb | at | Ohio | @ MAC (1A) | |||||
| Southern Illinois | at | SE Missouri State | MVC | |||||
| Charleston Southern | at | William & Mary | @ CAAF | |||||
| 9/27/2025 | South Carolina State | at | Charleston Southern | MEAC | ||||
| Lindenwood | at | Miami-Ohio | @ MAC (1A) | |||||
| Tennessee Tech | at | Tennessee State | ||||||
| SE Missouri State | at | Tennessee-Martin | ||||||
| Eastern Illinois | at | Western Illinois | ||||||
| 9/28/2025 | Lindenwood | at | St Thomas | @ Pio | ||||
| 10/4/2025 | Tennessee State | at | Eastern Illinois | |||||
| Charleston Southern | at | Gardner-Webb | ||||||
| Tennessee-Martin | at | Lindenwood | ||||||
| Western Illinois | at | Tennessee Tech | ||||||
| 10/11/2025 | Tennessee Tech | at | Charleston Southern | |||||
| Gardner-Webb | at | Eastern Illinois | ||||||
| Tennessee State | at | SE Missouri State | ||||||
| Western Illinois | at | Tennessee-Martin | ||||||
| 10/18/2025 | Tennessee-Martin | at | Gardner-Webb | |||||
| Tennessee Tech | at | Lindenwood | ||||||
| Eastern Illinois | at | SE Missouri State | ||||||
| Howard | at | Tennessee State | MEAC | |||||
| Charleston Southern | at | Western Illinois | ||||||
| 10/25/2025 | Eastern Illinois | at | Charleston Southern | |||||
| Gardner-Webb | at | Lindenwood | ||||||
| Western Illinois | at | Tennessee State | ||||||
| SE Missouri State | at | Tennessee Tech | ||||||
| 11/1/2025 | Tennessee-Martin | at | Eastern Illinois | |||||
| Charleston Southern | at | SE Missouri State | ||||||
| Lindenwood | at | Tennessee State | ||||||
| Gardner-Webb | at | Tennessee Tech | ||||||
| 11/8/2025 | Tennessee Tech | at | Eastern Illinois | |||||
| SE Missouri State | at | Gardner-Webb | ||||||
| Tennessee State | at | Tennessee-Martin | ||||||
| Lindenwood | at | Western Illinois | ||||||
| 11/15/2025 | Tennessee Tech | at | Kentucky | @ SEC (1A) | ||||
| Eastern Illinois | at | Lindenwood | ||||||
| Gardner-Webb | at | Tennessee State | ||||||
| Charleston Southern | at | Tennessee-Martin | ||||||
| SE Missouri State | at | Western Illinois | ||||||
| 11/22/2025 | Eastern Illinois | at | Alabama | @ SEC (1A) | ||||
| Tennessee State | at | Charleston Southern | ||||||
| Western Illinois | at | Gardner-Webb | ||||||
| Lindenwood | at | SE Missouri State | ||||||
| Tennessee-Martin | at | Tennessee Tech |