| 8/28/2025 | Buffalo | at | Minnesota | MAC | ||||
| Cincinnati | vs | Nebraska | Kansas City MO | vs B12 | ||||
| Ohio | at | Rutgers | MAC | |||||
| Miami-Ohio | at | Wisconsin | MAC | |||||
| 8/29/2025 | Western Illinois | at | Illinois | BigS (1AA) | ||||
| Western Michigan | at | Michigan State | MAC | |||||
| 8/30/2025 | Old Dominion | at | Indiana | SBC | ||||
| Albany NY | at | Iowa | CAAF (1AA) | |||||
| Florida Atlantic | at | Maryland | AAC | |||||
| New Mexico | at | Michigan | MW | |||||
| Texas | at | Ohio State | SEC | |||||
| Montana State | at | Oregon | BSky (1AA) | |||||
| Nevada | at | Penn State | MW | |||||
| Ball State | at | Purdue | MAC | |||||
| Missouri State | at | Southern California | CUSA | |||||
| Northwestern | at | Tulane | @ AAC | |||||
| Utah | at | UCLA | B12 | |||||
| Colorado State | at | Washington | MW | |||||
| 9/5/2025 | Northern Illinois | at | Maryland | MAC | ||||
| Western Illinois | at | Northwestern | BigS (1AA) | |||||
| 9/6/2025 | Illinois | at | Duke | @ ACC | ||||
| Kennesaw St | at | Indiana | CUSA | |||||
| Iowa | at | Iowa State | @ B12 | |||||
| Boston College | at | Michigan State | ACC | |||||
| Northwestern State | at | Minnesota | SLC (1AA) | |||||
| Akron | at | Nebraska | MAC | |||||
| Grambling | at | Ohio State | SWAC (1AA) | |||||
| Michigan | at | Oklahoma | @ SEC | |||||
| Oklahoma State | at | Oregon | B12 | |||||
| Florida Intl | at | Penn State | CUSA | |||||
| Southern Illinois | at | Purdue | MVC (1AA) | |||||
| Miami-Ohio | at | Rutgers | MAC | |||||
| Georgia Southern | at | Southern California | SBC | |||||
| UCLA | at | UNLV | @ MW | |||||
| UC Davis | at | Washington | BSky (1AA) | |||||
| Middle Tenn State | at | Wisconsin | CUSA | |||||
| 9/12/2025 | Indiana State | at | Indiana | MVC (1AA) | ||||
| New Mexico | at | UCLA | MW | |||||
| 9/13/2025 | Wisconsin | at | Alabama | @ SEC | ||||
| Minnesota | at | California | @ ACC | |||||
| Western Michigan | at | Illinois | MAC | |||||
| Massachusetts | at | Iowa | MAC | |||||
| Towson | at | Maryland | CAAF (1AA) | |||||
| Central Michigan | at | Michigan | MAC | |||||
| Youngstown State | at | Michigan State | MVC (1AA) | |||||
| Houston Christian | at | Nebraska | SLC (1AA) | |||||
| Oregon | at | Northwestern | ||||||
| Ohio | at | Ohio State | MAC | |||||
| Villanova | at | Penn State | CAAF (1AA) | |||||
| Southern California | at | Purdue | ||||||
| Norfolk State | at | Rutgers | MEAC (1AA) | |||||
| 9/19/2025 | Iowa | at | Rutgers | |||||
| 9/20/2025 | Illinois | at | Indiana | |||||
| Michigan | at | Nebraska | ||||||
| Purdue | at | Notre Dame | @ ND | |||||
| Oregon State | at | Oregon | Ind | |||||
| Michigan State | at | Southern California | ||||||
| Washington | at | Washington State | @ Ind | |||||
| Maryland | at | Wisconsin | ||||||
| 9/27/2025 | Southern California | at | Illinois | |||||
| Indiana | at | Iowa | ||||||
| Rutgers | at | Minnesota | ||||||
| UCLA | at | Northwestern | ||||||
| Oregon | at | Penn State | ||||||
| Ohio State | at | Washington | ||||||
| 10/4/2025 | Washington | at | Maryland | |||||
| Wisconsin | at | Michigan | ||||||
| Michigan State | at | Nebraska | ||||||
| UL Monroe | at | Northwestern | SBC | |||||
| Minnesota | at | Ohio State | ||||||
| Illinois | at | Purdue | ||||||
| Penn State | at | UCLA | ||||||
| 10/10/2025 | Rutgers | at | Washington | |||||
| 10/11/2025 | Ohio State | at | Illinois | |||||
| Nebraska | at | Maryland | ||||||
| UCLA | at | Michigan State | ||||||
| Purdue | at | Minnesota | ||||||
| Indiana | at | Oregon | ||||||
| Northwestern | at | Penn State | ||||||
| Michigan | at | Southern California | ||||||
| Iowa | at | Wisconsin | ||||||
| 10/17/2025 | Nebraska | at | Minnesota | |||||
| 10/18/2025 | Michigan State | at | Indiana | |||||
| Penn State | at | Iowa | ||||||
| Washington | at | Michigan | ||||||
| Purdue | at | Northwestern | ||||||
| Southern California | at | Notre Dame | @ ND | |||||
| Oregon | at | Rutgers | ||||||
| Maryland | at | UCLA | ||||||
| Ohio State | at | Wisconsin | ||||||
| 10/25/2025 | UCLA | at | Indiana | |||||
| Minnesota | at | Iowa | ||||||
| Michigan | at | Michigan State | ||||||
| Northwestern | at | Nebraska | ||||||
| Wisconsin | at | Oregon | ||||||
| Rutgers | at | Purdue | ||||||
| Illinois | at | Washington | ||||||
| 11/1/2025 | Rutgers | at | Illinois | |||||
| Indiana | at | Maryland | ||||||
| Purdue | at | Michigan | ||||||
| Michigan State | at | Minnesota | ||||||
| Southern California | at | Nebraska | ||||||
| Penn State | at | Ohio State | ||||||
| 11/7/2025 | Northwestern | at | Southern California | |||||
| 11/8/2025 | Oregon | at | Iowa | |||||
| Indiana | at | Penn State | ||||||
| Ohio State | at | Purdue | ||||||
| Maryland | at | Rutgers | ||||||
| Nebraska | at | UCLA | ||||||
| Washington | at | Wisconsin | ||||||
| 11/14/2025 | Minnesota | at | Oregon | |||||
| 11/15/2025 | Maryland | at | Illinois | |||||
| Wisconsin | at | Indiana | ||||||
| Penn State | at | Michigan State | ||||||
| Michigan | vs | Northwestern | Chicago IL | |||||
| UCLA | at | Ohio State | ||||||
| Iowa | at | Southern California | ||||||
| Purdue | at | Washington | ||||||
| 11/22/2025 | Michigan State | at | Iowa | |||||
| Michigan | at | Maryland | ||||||
| Minnesota | vs | Northwestern | Chicago IL | |||||
| Rutgers | at | Ohio State | ||||||
| Southern California | at | Oregon | ||||||
| Nebraska | at | Penn State | ||||||
| Washington | at | UCLA | ||||||
| Illinois | at | Wisconsin | ||||||
| 11/28/2025 | Iowa | at | Nebraska | |||||
| Indiana | at | Purdue | ||||||
| 11/29/2025 | Northwestern | at | Illinois | |||||
| Ohio State | at | Michigan | ||||||
| Maryland | vs | Michigan State | Detroit MI | |||||
| Wisconsin | at | Minnesota | ||||||
| Penn State | at | Rutgers | ||||||
| UCLA | at | Southern California | ||||||
| Oregon | at | Washington |