| 8/28/2025 | Point | at | Faulkner | @ MSC | ||||
| Cumberlands KY | at | Union KY | MSC | |||||
| 8/30/2025 | Thomas GA | at | Bluefield VA | Sun | ||||
| Pikeville | at | Georgetown KY | @ MSC | |||||
| Florida Memorial | at | Reinhardt | Sun | |||||
| Defiance | at | Rio Grande | MSFA | |||||
| 9/6/2025 | Kentucky Christian | at | Brevard | @ USASC (D3) | ||||
| Reinhardt | at | Cumberland TN | @ MSC | |||||
| Bluefield VA | at | Cumberlands KY | @ MSC | |||||
| LaGrange | at | Point | USASC (D3) | |||||
| Georgetown KY | at | Rio Grande | MSC | |||||
| Thomas GA | at | Union KY | Sun | |||||
| 9/13/2025 | Pikeville | at | Campbellsville | @ MSC | ||||
| Point | at | Newberry | @ SAC (D2) | |||||
| Reinhardt | at | Southeastern FL | @ Sun | |||||
| Kentucky Christian | at | Taylor | @ MSFA | |||||
| 9/20/2025 | Rio Grande | at | Ferris State | @ GLIAC (D2) | ||||
| Kentucky Christian | at | Morehead State | @ Pio (1AA) | |||||
| Cumberland TN | at | Pikeville | MSC | |||||
| Bluefield VA | at | Presbyterian | @ Pio (1AA) | |||||
| Lindsey Wilson | at | Reinhardt | MSC | |||||
| 9/27/2025 | Virginia U-Lynchburg | at | Bluefield VA | None (Unk?) | ||||
| Pikeville | at | Maryville | @ SAA (D3) | |||||
| Faulkner | at | Union KY | MSC | |||||
| 10/4/2025 | Bluefield VA | at | Point | |||||
| Union KY | at | Reinhardt | ||||||
| Kentucky Christian | at | Rio Grande | ||||||
| 10/11/2025 | Reinhardt | at | Kentucky Christian | |||||
| Rio Grande | at | Pikeville | ||||||
| Point | at | Union KY | ||||||
| 10/18/2025 | Kentucky Christian | at | Central State | @ SIAC (D2) | ||||
| Point | at | Pikeville | ||||||
| Bluefield VA | at | Reinhardt | ||||||
| Union KY | at | Rio Grande | ||||||
| 10/25/2025 | Pikeville | at | Bluefield VA | |||||
| Rio Grande | at | Point | ||||||
| Kentucky Christian | at | Union KY | ||||||
| 11/1/2025 | Bluefield VA | at | Kentucky Christian | |||||
| Union KY | at | Pikeville | ||||||
| Reinhardt | at | Rio Grande | ||||||
| 11/8/2025 | Rio Grande | at | Bluefield VA | |||||
| Kentucky Christian | at | Pikeville | ||||||
| Point | at | Reinhardt | ||||||
| 11/15/2025 | Union KY | at | Bluefield VA | |||||
| Point | at | Kentucky Christian | ||||||
| Pikeville | at | Reinhardt |