| 8/23/2025 | Stanford | at | Hawaii | @ MW | ||||
| 8/28/2025 | Elon | at | Duke | CAAF (1AA) | ||||
| East Carolina | at | North Carolina State | AAC | |||||
| 8/29/2025 | Georgia Tech | at | Colorado | @ B12 | ||||
| Kennesaw St | at | Wake Forest | CUSA | |||||
| 8/30/2025 | Fordham | at | Boston College | Pat (1AA) | ||||
| LSU | at | Clemson | SEC | |||||
| Alabama | at | Florida State | SEC | |||||
| Eastern Kentucky | at | Louisville | UAC (1AA) | |||||
| California | at | Oregon State | @ Ind | |||||
| Duquesne | at | Pittsburgh | NE (1AA) | |||||
| East Texas A&M | at | SMU | SLC (1AA) | |||||
| Syracuse | vs | Tennessee | Atlanta GA | vs SEC | ||||
| Coastal Carolina | at | Virginia | SBC | |||||
| 8/31/2025 | Notre Dame | at | Miami-Florida | ND | ||||
| Virginia Tech | vs | South Carolina | Atlanta GA | vs SEC | ||||
| 9/1/2025 | TCU | at | North Carolina | B12 | ||||
| 9/5/2025 | James Madison | at | Louisville | SBC | ||||
| 9/6/2025 | Stanford | at | BYU | @ B12 | ||||
| Texas Southern | at | California | SWAC (1AA) | |||||
| Troy | at | Clemson | SBC | |||||
| Illinois | at | Duke | B10 | |||||
| East Texas A&M | at | Florida State | SLC (1AA) | |||||
| Gardner-Webb | at | Georgia Tech | BigS (1AA) | |||||
| Bethune-Cookman | at | Miami-Florida | SWAC (1AA) | |||||
| Boston College | at | Michigan State | @ B10 | |||||
| Virginia | at | North Carolina State | ||||||
| Central Michigan | at | Pittsburgh | MAC | |||||
| Baylor | at | SMU | B12 | |||||
| Connecticut | at | Syracuse | Ind | |||||
| North Carolina | at | UNC-Charlotte | @ AAC | |||||
| Vanderbilt | at | Virginia Tech | SEC | |||||
| Western Carolina | at | Wake Forest | SoCon (1AA) | |||||
| 9/11/2025 | North Carolina State | at | Wake Forest | |||||
| 9/12/2025 | Colgate | at | Syracuse | Pat (1AA) | ||||
| 9/13/2025 | Minnesota | at | California | B10 | ||||
| Clemson | at | Georgia Tech | ||||||
| South Florida | at | Miami-Florida | AAC | |||||
| SMU | at | Missouri State | @ CUSA | |||||
| Richmond | at | North Carolina | Pat (1AA) | |||||
| Boston College | at | Stanford | ||||||
| Duke | at | Tulane | @ AAC | |||||
| William & Mary | at | Virginia | CAAF (1AA) | |||||
| Old Dominion | at | Virginia Tech | SBC | |||||
| Pittsburgh | at | West Virginia | @ B12 | |||||
| 9/20/2025 | North Carolina | at | UCF | @ B12 | ||||
| Syracuse | at | Clemson | ||||||
| North Carolina State | at | Duke | ||||||
| Kent State | at | Florida State | MAC | |||||
| Temple | at | Georgia Tech | AAC | |||||
| Bowling Green | at | Louisville | MAC | |||||
| Florida | at | Miami-Florida | SEC | |||||
| California | at | San Diego State | @ MW | |||||
| SMU | at | TCU | @ B12 | |||||
| Stanford | at | Virginia | ||||||
| Wofford | at | Virginia Tech | SoCon (1AA) | |||||
| 9/26/2025 | Florida State | at | Virginia | |||||
| 9/27/2025 | California | at | Boston College | |||||
| Virginia Tech | at | North Carolina State | ||||||
| Louisville | at | Pittsburgh | ||||||
| Duke | at | Syracuse | ||||||
| Georgia Tech | at | Wake Forest | ||||||
| 10/4/2025 | Duke | at | California | |||||
| Miami-Florida | at | Florida State | ||||||
| Virginia | at | Louisville | ||||||
| Clemson | at | North Carolina | ||||||
| Campbell | at | North Carolina State | CAAF (1AA) | |||||
| Boston College | at | Pittsburgh | ||||||
| Syracuse | at | SMU | ||||||
| Wake Forest | at | Virginia Tech | ||||||
| 10/11/2025 | Clemson | at | Boston College | |||||
| Pittsburgh | at | Florida State | ||||||
| Virginia Tech | at | Georgia Tech | ||||||
| North Carolina State | at | Notre Dame | @ ND | |||||
| Wake Forest | at | Oregon State | @ Ind | |||||
| Stanford | at | SMU | ||||||
| 10/17/2025 | North Carolina | at | California | |||||
| Louisville | at | Miami-Florida | ||||||
| 10/18/2025 | Connecticut | at | Boston College | Ind | ||||
| SMU | at | Clemson | ||||||
| Georgia Tech | at | Duke | ||||||
| Florida State | at | Stanford | ||||||
| Pittsburgh | at | Syracuse | ||||||
| Washington State | at | Virginia | Ind | |||||
| 10/24/2025 | California | at | Virginia Tech | |||||
| 10/25/2025 | Syracuse | at | Georgia Tech | |||||
| Boston College | at | Louisville | ||||||
| Stanford | at | Miami-Florida | ||||||
| Virginia | at | North Carolina | ||||||
| North Carolina State | at | Pittsburgh | ||||||
| SMU | at | Wake Forest | ||||||
| 10/27/2025 | San Jose State | at | Stanford | MW | ||||
| 10/31/2025 | North Carolina | at | Syracuse | |||||
| 11/1/2025 | Notre Dame | at | Boston College | ND | ||||
| Virginia | at | California | ||||||
| Duke | at | Clemson | ||||||
| Wake Forest | at | Florida State | ||||||
| Georgia Tech | at | North Carolina State | ||||||
| Miami-Florida | at | SMU | ||||||
| Pittsburgh | at | Stanford | ||||||
| Louisville | at | Virginia Tech | ||||||
| 11/8/2025 | SMU | at | Boston College | |||||
| Florida State | at | Clemson | ||||||
| Duke | at | Connecticut | @ Ind | |||||
| California | at | Louisville | ||||||
| Syracuse | at | Miami-Florida | ||||||
| Stanford | at | North Carolina | ||||||
| Wake Forest | at | Virginia | ||||||
| 11/14/2025 | Clemson | at | Louisville | |||||
| 11/15/2025 | Georgia Tech | at | Boston College | |||||
| Virginia | at | Duke | ||||||
| Virginia Tech | at | Florida State | ||||||
| North Carolina State | at | Miami-Florida | ||||||
| Notre Dame | at | Pittsburgh | ND | |||||
| North Carolina | at | Wake Forest | ||||||
| 11/21/2025 | Florida State | at | North Carolina State | |||||
| 11/22/2025 | Furman | at | Clemson | SoCon (1AA) | ||||
| Pittsburgh | at | Georgia Tech | ||||||
| Duke | at | North Carolina | ||||||
| Syracuse | at | Notre Dame | @ ND | |||||
| Louisville | at | SMU | ||||||
| California | at | Stanford | ||||||
| Miami-Florida | at | Virginia Tech | ||||||
| Delaware | at | Wake Forest | CUSA | |||||
| 11/28/2025 | Georgia | at | Georgia Tech | SEC | ||||
| 11/29/2025 | SMU | at | California | |||||
| Wake Forest | at | Duke | ||||||
| Florida State | at | Florida | @ SEC | |||||
| Kentucky | at | Louisville | SEC | |||||
| North Carolina | at | North Carolina State | ||||||
| Miami-Florida | at | Pittsburgh | ||||||
| Clemson | at | South Carolina | @ SEC | |||||
| Notre Dame | at | Stanford | ND | |||||
| Boston College | at | Syracuse | ||||||
| Virginia Tech | at | Virginia |