| 8/29/2024 | Northern State (6-5) | 3 | at | South Dakota | 45 | NSIC (D2) | ||
| 9/7/2024 | South Dakota | 13 | at | Wisconsin (5-5) | 27 | at B10 | ||
| 9/21/2024 | Drake (7-2) | 3 | at | South Dakota | 42 | Pio | ||
| 9/28/2024 | Southern Illinois (3-8,1-6) | 13 | at | South Dakota | 42 | |||
| 10/5/2024 | South Dakota | 59 | at | Murray State (1-10,0-7) | 0 | |||
| 10/12/2024 | Northern Iowa (2-9,0-7) | 17 | at | South Dakota | 42 | |||
| 10/19/2024 | South Dakota | 27 | at | Youngstown State (4-8,3-5) | 17 | |||
| 10/26/2024 | South Dakota | 17 | at | South Dakota State (9-2,6-1) | 20 | OT | ||
| 11/9/2024 | Indiana State (4-7,3-4) | 0 | at | South Dakota | 49 | |||
| 11/16/2024 | South Dakota | 42 | at | North Dakota (5-6,2-5) | 36 | |||
| 11/23/2024 | North Dakota State (10-1,7-0) | at | South Dakota |
| vs South Dakota | vs Other Opponents | South Dakota compared to OOs | |
| Record: | 2-8 | 54-55 | |
| Points Scored: | 13.60 | 26.36 | 12.76 |
| Points Allowed: | 37.80 | 27.04 | 10.76 |
| Margin: | -24.20 | -0.68 | 23.52 |
| Total Points: | 51.40 | 53.40 | -2.00 |