| 8/29/2024 | Northern State (5-5) | 3 | at | South Dakota | 45 | NSIC (D2) | ||
| 9/7/2024 | South Dakota | 13 | at | Wisconsin (5-4) | 27 | at B10 | ||
| 9/21/2024 | Drake (6-1) | 3 | at | South Dakota | 42 | Pio | ||
| 9/28/2024 | Southern Illinois (2-7,0-5) | 13 | at | South Dakota | 42 | |||
| 10/5/2024 | South Dakota | 59 | at | Murray State (1-8,0-6) | 0 | |||
| 10/12/2024 | Northern Iowa (2-7,0-5) | 17 | at | South Dakota | 42 | |||
| 10/19/2024 | South Dakota | 27 | at | Youngstown State (3-7,2-4) | 17 | |||
| 10/26/2024 | South Dakota | 17 | at | South Dakota State (7-2,4-1) | 20 | OT | ||
| 11/9/2024 | Indiana State (4-5,3-2) | at | South Dakota | |||||
| 11/16/2024 | South Dakota | at | North Dakota (5-4,2-3) | |||||
| 11/23/2024 | North Dakota State (9-1,6-0) | at | South Dakota |
| vs South Dakota | vs Other Opponents | South Dakota compared to OOs | |
| Record: | 2-6 | 47-45 | |
| Points Scored: | 12.50 | 26.34 | 13.84 |
| Points Allowed: | 35.88 | 26.40 | 9.48 |
| Margin: | -23.38 | -0.06 | 23.32 |
| Total Points: | 48.38 | 52.74 | -4.36 |