| 8/30/2024 | Florida Atlantic (3-9) | 10 | at | Michigan State | 16 | AAC | ||
| 9/7/2024 | Michigan State | 27 | at | Maryland (4-8,1-8) | 24 | |||
| 9/14/2024 | Prairie View (5-7) | 0 | at | Michigan State | 40 | SWAC (1AA) | ||
| 9/21/2024 | Michigan State | 19 | at | Boston College (7-6) | 23 | at ACC | ||
| 9/28/2024 | Ohio State (14-2,8-2) | 38 | at | Michigan State | 7 | |||
| 10/4/2024 | Michigan State | 10 | at | Oregon (13-1,10-1) | 31 | |||
| 10/19/2024 | Iowa (8-5,6-3) | 20 | at | Michigan State | 32 | |||
| 10/26/2024 | Michigan State | 17 | at | Michigan (8-5,5-4) | 24 | |||
| 11/2/2024 | Indiana (11-2,8-1) | 47 | at | Michigan State | 10 | |||
| 11/16/2024 | Michigan State | 16 | at | Illinois (10-3,6-3) | 38 | |||
| 11/22/2024 | Purdue (1-11,0-9) | 17 | at | Michigan State | 24 | |||
| 11/30/2024 | Rutgers (7-6,4-5) | 41 | at | Michigan State | 14 |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 7-5 | 84-60 | |
| Points Scored: | 26.08 | 28.30 | 2.22 |
| Points Allowed: | 19.33 | 23.53 | -4.20 |
| Margin: | 6.75 | 4.77 | -1.98 |
| Total Points: | 45.41 | 51.83 | -6.42 |