| 8/30/2024 | Florida Atlantic (2-8) | 10 | at | Michigan State | 16 | AAC | ||
| 9/7/2024 | Michigan State | 27 | at | Maryland (4-6,1-6) | 24 | |||
| 9/14/2024 | Prairie View (5-6) | 0 | at | Michigan State | 40 | SWAC (1AA) | ||
| 9/21/2024 | Michigan State | 19 | at | Boston College (5-5) | 23 | at ACC | ||
| 9/28/2024 | Ohio State (9-1,6-1) | 38 | at | Michigan State | 7 | |||
| 10/4/2024 | Michigan State | 10 | at | Oregon (11-0,8-0) | 31 | |||
| 10/19/2024 | Iowa (6-4,4-3) | 20 | at | Michigan State | 32 | |||
| 10/26/2024 | Michigan State | 17 | at | Michigan (5-5,3-4) | 24 | |||
| 11/2/2024 | Indiana (10-0,7-0) | 47 | at | Michigan State | 10 | |||
| 11/16/2024 | Michigan State | 16 | at | Illinois (7-3,4-3) | 38 | |||
| 11/22/2024 | Purdue (1-9,0-7) | at | Michigan State | |||||
| 11/30/2024 | Rutgers (6-4,3-4) | at | Michigan State |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 6-4 | 65-47 | |
| Points Scored: | 25.50 | 28.09 | 2.59 |
| Points Allowed: | 19.40 | 23.46 | -4.06 |
| Margin: | 6.10 | 4.63 | -1.47 |
| Total Points: | 44.90 | 51.55 | -6.65 |