| 8/30/2024 | Florida Atlantic (2-6) | 10 | at | Michigan State | 16 | AAC | ||
| 9/7/2024 | Michigan State | 27 | at | Maryland (4-4,1-4) | 24 | |||
| 9/14/2024 | Prairie View (4-5) | 0 | at | Michigan State | 40 | SWAC (1AA) | ||
| 9/21/2024 | Michigan State | 19 | at | Boston College (4-4) | 23 | at ACC | ||
| 9/28/2024 | Ohio State (7-1,4-1) | 38 | at | Michigan State | 7 | |||
| 10/4/2024 | Michigan State | 10 | at | Oregon (9-0,6-0) | 31 | |||
| 10/19/2024 | Iowa (6-3,4-2) | 20 | at | Michigan State | 32 | |||
| 10/26/2024 | Michigan State | 17 | at | Michigan (5-4,3-3) | 24 | |||
| 11/2/2024 | Indiana (9-0,6-0) | 47 | at | Michigan State | 10 | |||
| 11/16/2024 | Michigan State | at | Illinois (6-3,3-3) | |||||
| 11/22/2024 | Purdue (1-7,0-5) | at | Michigan State | |||||
| 11/30/2024 | Rutgers (4-4,1-4) | at | Michigan State |
| vs Michigan State | vs Other Opponents | Michigan State compared to OOs | |
| Record: | 5-4 | 56-37 | |
| Points Scored: | 24.11 | 29.28 | 5.17 |
| Points Allowed: | 19.78 | 23.23 | -3.45 |
| Margin: | 4.33 | 6.05 | 1.72 |
| Total Points: | 43.89 | 52.51 | -8.62 |