| 8/31/2024 | North Dakota (5-4) | 3 | at | Iowa State | 21 | MVC (1AA) | ||
| 9/7/2024 | Iowa State | 20 | at | Iowa (6-3) | 19 | at B10 | ||
| 9/21/2024 | Arkansas State (5-3) | 7 | at | Iowa State | 52 | SBC | ||
| 9/28/2024 | Iowa State | 20 | at | Houston (4-5,3-3) | 0 | |||
| 10/5/2024 | Baylor (5-4,3-4) | 21 | at | Iowa State | 43 | |||
| 10/12/2024 | Iowa State | 28 | at | West Virginia (4-4,3-2) | 16 | |||
| 10/19/2024 | UCF (4-5,2-4) | 35 | at | Iowa State | 38 | |||
| 11/2/2024 | Texas Tech (6-3,4-2) | 23 | at | Iowa State | 22 | |||
| 11/9/2024 | Iowa State | vs | Kansas (2-6,1-4) | Kansas City MO | ||||
| 11/16/2024 | Cincinnati (5-3,3-2) | at | Iowa State | |||||
| 11/23/2024 | Iowa State | at | Utah (4-4,2-4) | |||||
| 11/30/2024 | Kansas State (7-2,5-2) | at | Iowa State |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 1-7 | 56-39 | |
| Points Scored: | 15.50 | 30.43 | 14.93 |
| Points Allowed: | 30.50 | 24.45 | 6.05 |
| Margin: | -15.00 | 5.98 | 20.98 |
| Total Points: | 46.00 | 54.88 | -8.88 |