| 8/31/2024 | North Dakota (5-6) | 3 | at | Iowa State | 21 | MVC (1AA) | ||
| 9/7/2024 | Iowa State | 20 | at | Iowa (6-4) | 19 | at B10 | ||
| 9/21/2024 | Arkansas State (6-4) | 7 | at | Iowa State | 52 | SBC | ||
| 9/28/2024 | Iowa State | 20 | at | Houston (4-6,3-4) | 0 | |||
| 10/5/2024 | Baylor (6-4,4-4) | 21 | at | Iowa State | 43 | |||
| 10/12/2024 | Iowa State | 28 | at | West Virginia (5-5,4-3) | 16 | |||
| 10/19/2024 | UCF (4-6,2-5) | 35 | at | Iowa State | 38 | |||
| 11/2/2024 | Texas Tech (6-4,4-3) | 23 | at | Iowa State | 22 | |||
| 11/9/2024 | Iowa State | 36 | vs | Kansas (4-6,3-4) | 45 | Kansas City MO | ||
| 11/16/2024 | Cincinnati (5-5,3-4) | 17 | at | Iowa State | 34 | |||
| 11/23/2024 | Iowa State | at | Utah (4-6,2-6) | |||||
| 11/30/2024 | Kansas State (7-3,5-3) | at | Iowa State |
| vs Iowa State | vs Other Opponents | Iowa State compared to OOs | |
| Record: | 2-8 | 60-51 | |
| Points Scored: | 18.60 | 29.49 | 10.89 |
| Points Allowed: | 31.40 | 25.66 | 5.74 |
| Margin: | -12.80 | 3.83 | 16.63 |
| Total Points: | 50.00 | 55.15 | -5.15 |