| 8/29/2024 | Lafayette (4-5) | 13 | at | Buffalo | 30 | Pat (1AA) | ||
| 9/7/2024 | Buffalo | 0 | at | Missouri (6-2) | 38 | at SEC | ||
| 9/14/2024 | Massachusetts (2-7) | 3 | at | Buffalo | 34 | Ind | ||
| 9/21/2024 | Buffalo | 23 | at | Northern Illinois (4-4,1-3) | 20 | |||
| 9/28/2024 | Buffalo | 3 | at | Connecticut (6-3) | 47 | at Ind | ||
| 10/12/2024 | Toledo (6-3,3-2) | 15 | at | Buffalo | 30 | |||
| 10/19/2024 | Western Michigan (5-3,4-0) | 48 | at | Buffalo | 41 | |||
| 10/26/2024 | Buffalo | 16 | at | Ohio (5-3,3-1) | 47 | |||
| 11/2/2024 | Buffalo | 41 | at | Akron (2-7,1-4) | 30 | |||
| 11/12/2024 | Ball State (3-6,2-3) | at | Buffalo | |||||
| 11/20/2024 | Buffalo | at | Eastern Michigan (5-4,2-3) | |||||
| 11/26/2024 | Kent State (0-8,0-4) | at | Buffalo |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 4-5 | 44-50 | |
| Points Scored: | 29.00 | 25.13 | -3.87 |
| Points Allowed: | 24.22 | 28.77 | -4.55 |
| Margin: | 4.78 | -3.64 | -8.42 |
| Total Points: | 53.22 | 53.90 | -0.68 |