| 8/29/2024 | Lafayette (6-5) | 13 | at | Buffalo | 30 | Pat (1AA) | ||
| 9/7/2024 | Buffalo | 0 | at | Missouri (7-3) | 38 | at SEC | ||
| 9/14/2024 | Massachusetts (2-8) | 3 | at | Buffalo | 34 | Ind | ||
| 9/21/2024 | Buffalo | 23 | at | Northern Illinois (6-5,3-4) | 20 | |||
| 9/28/2024 | Buffalo | 3 | at | Connecticut (7-3) | 47 | at Ind | ||
| 10/12/2024 | Toledo (7-4,4-3) | 15 | at | Buffalo | 30 | |||
| 10/19/2024 | Western Michigan (5-6,4-3) | 48 | at | Buffalo | 41 | |||
| 10/26/2024 | Buffalo | 16 | at | Ohio (8-3,6-1) | 47 | |||
| 11/2/2024 | Buffalo | 41 | at | Akron (3-8,2-5) | 30 | |||
| 11/12/2024 | Ball State (3-7,2-4) | 48 | at | Buffalo | 51 | OT | ||
| 11/20/2024 | Buffalo | 37 | at | Eastern Michigan (5-6,2-5) | 20 | |||
| 11/26/2024 | Kent State (0-11,0-7) | at | Buffalo |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 4-7 | 55-62 | |
| Points Scored: | 29.91 | 24.93 | -4.98 |
| Points Allowed: | 27.82 | 27.75 | 0.07 |
| Margin: | 2.09 | -2.82 | -4.91 |
| Total Points: | 57.73 | 52.68 | 5.05 |