| 8/29/2024 | Lafayette (6-6) | 13 | at | Buffalo | 30 | Pat (1AA) | ||
| 9/7/2024 | Buffalo | 0 | at | Missouri (10-3) | 38 | at SEC | ||
| 9/14/2024 | Massachusetts (2-10) | 3 | at | Buffalo | 34 | Ind | ||
| 9/21/2024 | Buffalo | 23 | at | Northern Illinois (8-5,4-4) | 20 | |||
| 9/28/2024 | Buffalo | 3 | at | Connecticut (9-4) | 47 | at Ind | ||
| 10/12/2024 | Toledo (8-5,4-4) | 15 | at | Buffalo | 30 | |||
| 10/19/2024 | Western Michigan (6-7,5-3) | 48 | at | Buffalo | 41 | |||
| 10/26/2024 | Buffalo | 16 | at | Ohio (11-3,8-1) | 47 | |||
| 11/2/2024 | Buffalo | 41 | at | Akron (4-8,3-5) | 30 | |||
| 11/12/2024 | Ball State (3-9,2-6) | 48 | at | Buffalo | 51 | OT | ||
| 11/20/2024 | Buffalo | 37 | at | Eastern Michigan (5-7,2-6) | 20 | |||
| 11/26/2024 | Kent State (0-12,0-8) | 7 | at | Buffalo | 43 | |||
| 1/4/2025 | Buffalo | 26 | vs | Liberty (8-4) | 7 | Bahamas Bowl - Nassau | vs CUSA |
| vs Buffalo | vs Other Opponents | Buffalo compared to OOs | |
| Record: | 4-9 | 76-74 | |
| Points Scored: | 26.38 | 25.80 | -0.58 |
| Points Allowed: | 28.85 | 27.47 | 1.38 |
| Margin: | -2.47 | -1.67 | 0.80 |
| Total Points: | 55.23 | 53.27 | 1.96 |