| 9/7/2024 | Anderson | 0 | at | Alfred State | 13 | @ ECFC | ||
| Rose-Hulman | 14 | at | DePauw | 57 | @ NCA | |||
| Centre | 27 | at | Hanover | 12 | SAA | |||
| Bluffton | 6 | at | Kenyon | 13 | @ NCA | |||
| Muskingum | 42 | at | Mt St Joseph | 35 | OAC | |||
| Franklin | 7 | at | Ohio Northern | 45 | @ OAC | |||
| Manchester | 3 | at | Westminster MO | 23 | @ UMWAC | |||
| 9/13/2024 | Mt St Joseph | 28 | at | Hiram | 7 | @ NCA | ||
| 9/14/2024 | Bluffton | 21 | at | Albion | 56 | @ MIAA | ||
| Hanover | 0 | at | Butler | 53 | @ Pio (1AA) | |||
| Manchester | 27 | at | Concordia IL | 28 | @ NAC | |||
| Franklin | 6 | at | Hope | 48 | @ MIAA | |||
| Anderson | 20 | at | Oberlin | 6 | @ NCA | |||
| Trine | 39 | at | Rose-Hulman | 33 | MIAA | |||
| 9/21/2024 | Calvin | 66 | at | Anderson | 12 | MIAA (D2) | ||
| Trine | 52 | at | Bluffton | 20 | MIAA | |||
| Adrian | 42 | at | Franklin | 21 | MIAA | |||
| Olivet | 14 | at | Hanover | 56 | MIAA | |||
| Kalamazoo | 55 | at | Manchester | 0 | MIAA | |||
| Albion | 14 | at | Mt St Joseph | 49 | MIAA | |||
| Hope | 49 | at | Rose-Hulman | 7 | MIAA | |||
| 9/28/2024 | Ohio Wesleyan | 14 | at | Franklin | 27 | NCA | ||
| Anderson | 6 | at | Luther | 9 | @ ARC | |||
| Wisconsin-River Falls | 68 | at | Mt St Joseph | 9 | WIAC | |||
| 10/5/2024 | Anderson | 9 | at | Bluffton | 37 | |||
| Manchester | 3 | at | Defiance | 35 | @ MSFA (NAIA) | |||
| Mt St Joseph | 49 | at | Hanover | 41 | ||||
| Franklin | 14 | at | Rose-Hulman | 24 | ||||
| 10/12/2024 | Mt St Joseph | 49 | at | Anderson | 0 | |||
| Rose-Hulman | 16 | at | Hanover | 37 | ||||
| Bluffton | 42 | at | Manchester | 10 | ||||
| 10/19/2024 | Hanover | 35 | at | Anderson | 0 | |||
| Franklin | 49 | at | Manchester | 0 | ||||
| Bluffton | 27 | at | Mt St Joseph | 63 | ||||
| Defiance | 25 | at | Rose-Hulman | 29 | MSFA (NAIA) | |||
| 10/26/2024 | Rose-Hulman | 52 | at | Bluffton | 10 | |||
| Mt St Joseph | 46 | at | Franklin | 43 | ||||
| Hanover | 55 | at | Manchester | 7 | ||||
| 11/2/2024 | Anderson | 14 | at | Franklin | 35 | |||
| Bluffton | 13 | at | Hanover | 49 | ||||
| Manchester | 7 | at | Rose-Hulman | 70 | ||||
| 11/9/2024 | Rose-Hulman | 28 | at | Anderson | 9 | |||
| Franklin | 22 | at | Bluffton | 28 | ||||
| Hanover | 31 | at | Defiance | 7 | @ MSFA (NAIA) | |||
| Mt St Joseph | 43 | at | Manchester | 7 | ||||
| 11/16/2024 | Manchester | 17 | at | Anderson | 31 | |||
| Defiance | 23 | at | Bluffton | 21 | MSFA (NAIA) | |||
| Hanover | 31 | at | Franklin | 27 | ||||
| Rose-Hulman | 21 | at | Mt St Joseph | 38 | ||||
| 11/23/2024 | Mt St Joseph | at | John Carroll | @ OAC |