| 9/5/2024 | Carroll WI | 28 | at | Wisconsin-Stout | 16 | @ WIAC | ||
| 9/7/2024 | Elmhurst | 20 | at | Adrian | 55 | @ MIAA | ||
| Simpson | 13 | at | Augustana IL | 30 | ARC | |||
| Illinois Wesleyan | 14 | at | Central IA | 49 | @ ARC | |||
| Illinois College | 46 | at | Millikin | 21 | MidW | |||
| Ripon | 41 | at | North Park | 42 | MidW | |||
| Washington U | 44 | at | Rhodes | 20 | @ SAA | |||
| Carthage | 0 | at | St John's MN | 49 | @ MIA | |||
| Wheaton | 14 | at | Wisconsin-Oshkosh | 21 | @ WIAC | |||
| 9/14/2024 | North Central | 48 | at | Aurora | 21 | @ NAC | ||
| 9/21/2024 | North Central | 63 | at | Carthage | 0 | |||
| Illinois Wesleyan | 55 | at | Elmhurst | 7 | ||||
| Millikin | 0 | at | North Park | 44 | ||||
| Carroll WI | 7 | at | Washington U | 35 | ||||
| Augustana IL | 3 | at | Wheaton | 42 | ||||
| 9/28/2024 | Wheaton | 22 | at | Carroll WI | 10 | |||
| North Park | 21 | at | Elmhurst | 28 | ||||
| Carthage | 0 | at | Illinois Wesleyan | 35 | ||||
| Augustana IL | 24 | at | Millikin | 20 | ||||
| Washington U | 9 | at | North Central | 49 | ||||
| 10/5/2024 | North Park | 30 | at | Augustana IL | 27 | |||
| Millikin | 14 | at | Carroll WI | 49 | ||||
| Elmhurst | 23 | at | Carthage | 17 | ||||
| Washington U | 33 | at | Illinois Wesleyan | 23 | ||||
| North Central | 55 | at | Wheaton | 27 | ||||
| 10/12/2024 | Elmhurst | 21 | at | Augustana IL | 35 | |||
| North Central | 70 | at | Millikin | 14 | ||||
| Carroll WI | 26 | at | North Park | 30 | ||||
| Carthage | 16 | at | Washington U | 65 | ||||
| Illinois Wesleyan | 21 | at | Wheaton | 42 | ||||
| 10/19/2024 | Augustana IL | 20 | at | Carroll WI | 30 | |||
| Wheaton | 50 | at | Carthage | 13 | ||||
| Washington U | 49 | at | Elmhurst | 10 | ||||
| Millikin | 8 | at | Illinois Wesleyan | 51 | ||||
| North Park | 0 | at | North Central | 69 | ||||
| 10/26/2024 | North Central | 49 | at | Augustana IL | 10 | |||
| Carroll WI | 45 | at | Elmhurst | 14 | ||||
| Carthage | 24 | at | Millikin | 20 | ||||
| Illinois Wesleyan | 24 | at | North Park | 28 | ||||
| Wheaton | 27 | at | Washington U | 20 | ||||
| 11/2/2024 | North Park | 21 | at | Carthage | 22 | |||
| Augustana IL | 21 | at | Illinois Wesleyan | 29 | ||||
| Carroll WI | 3 | at | North Central | 56 | ||||
| Millikin | 21 | at | Washington U | 70 | ||||
| Elmhurst | 17 | at | Wheaton | 65 | ||||
| 11/9/2024 | Carthage | 21 | at | Augustana IL | 31 | |||
| Illinois Wesleyan | 24 | at | Carroll WI | 21 | ||||
| Wheaton | 64 | at | Millikin | 10 | ||||
| Elmhurst | 7 | at | North Central | 70 | ||||
| Washington U | 28 | at | North Park | 21 | ||||
| 11/16/2024 | Carthage | 7 | at | Carroll WI | 27 | |||
| Millikin | 7 | at | Elmhurst | 35 | ||||
| North Central | 42 | at | Illinois Wesleyan | 20 | ||||
| Augustana IL | 24 | at | Washington U | 45 | ||||
| North Park | 14 | at | Wheaton | 66 | ||||
| 11/23/2024 | Wisconsin-Stout | 32 | at | Wheaton | 35 | WIAC | ||
| 11/30/2024 | Whitworth | 17 | at | North Central | 42 | D3 Playoffs Round 2 | NWC | |
| 12/7/2024 | Hope | 21 | at | North Central | 41 | D3 Round 3 | MIAA | |
| 12/14/2024 | Springfield | 3 | at | North Central | 27 | D3 Quarterfinal | NEWMAC | |
| 12/21/2024 | Susquehanna | 0 | at | North Central | 66 | D3 Semifinal | LM | |
| 1/5/2025 | Mount Union | 25 | vs | North Central | 41 | D3 Championship - Houston TX | vs OAC |