| 9/1/2022 | Notre Dame OH | 14 | at | Ashland (10-2) | 31 | | | at GMAC |
| 9/10/2022 | Wheeling (7-4,6-4) | 14 | at | Notre Dame OH | 27 | | | |
| 9/17/2022 | West Liberty (4-7,3-7) | 17 | at | Notre Dame OH | 34 | | | |
| 9/24/2022 | Notre Dame OH | 48 | at | West Virginia State (7-4,6-4) | 13 | | | |
| 10/1/2022 | Charleston WV (6-5,6-4) | 24 | at | Notre Dame OH | 49 | | | |
| 10/8/2022 | Notre Dame OH | 30 | at | Frostburg State (8-3,7-3) | 33 | 2OT | | |
| 10/15/2022 | Notre Dame OH | 41 | at | West Virginia Wesleyan (1-10,1-9) | 9 | | | |
| 10/22/2022 | Glenville State (7-4,6-4) | 16 | at | Notre Dame OH | 38 | | | |
| 10/29/2022 | Notre Dame OH | 30 | at | Fairmont State (3-8,3-7) | 6 | | | |
| 11/5/2022 | UNC Pembroke (5-6,5-5) | 0 | at | Notre Dame OH | 27 | | | |
| 11/12/2022 | Notre Dame OH | 27 | at | Alderson-Broaddus (0-11,0-10) | 3 | | | |
| 11/19/2022 | Notre Dame OH | 13 | at | Ashland (10-2) | 20 | | D2 Championship Round 1 | at GMAC |