| 9/1/2022 | Central Oklahoma | 0 | at | Missouri Western (5-6,5-6) | 35 | | | |
| 9/8/2022 | Emporia State (9-3,8-3) | 13 | at | Central Oklahoma | 21 | | | |
| 9/17/2022 | Central Oklahoma | 21 | at | Missouri Southern (4-7,4-7) | 40 | | | |
| 9/24/2022 | Northwest Missouri State (10-3,9-2) | 14 | at | Central Oklahoma | 23 | | | |
| 10/1/2022 | Central Oklahoma | 45 | at | Lincoln MO (0-11,0-11) | 3 | | | |
| 10/6/2022 | Northeastern State (1-10,1-10) | 6 | at | Central Oklahoma | 55 | | | |
| 10/15/2022 | Fort Hays State (3-8,3-8) | 23 | at | Central Oklahoma | 35 | | | |
| 10/22/2022 | Central Oklahoma | 9 | at | Washburn (7-4,7-4) | 37 | | | |
| 10/29/2022 | Pittsburg State (12-1,11-0) | 38 | at | Central Oklahoma | 7 | | | |
| 11/5/2022 | Central Oklahoma | 18 | at | Nebraska-Kearney (8-3,8-3) | 20 | | | |
| 11/12/2022 | Central Missouri (4-7,4-7) | 10 | at | Central Oklahoma | 13 | | | |