| 8/27/2022 | Howard | 13 | vs | Alabama State | 23 | Atlanta GA | vs SWAC | |
| 9/1/2022 | South Carolina State | 10 | at | UCF | 56 | @ AAC (1A) | ||
| 9/3/2022 | Lincoln PA | 0 | at | Delaware State | 34 | CIAA (D2) | ||
| Morgan State | 7 | at | Georgia Southern | 59 | @ SBC (1A) | |||
| Howard | 28 | at | Hampton | 31 | @ CAAF | |||
| Norfolk State | 3 | at | Marshall | 55 | @ SBC (1A) | |||
| North Carolina A&T | 13 | vs | North Carolina Central | 28 | Charlotte NC | vs BigS | ||
| 9/10/2022 | South Carolina State | 33 | at | Bethune-Cookman | 9 | @ SWAC | ||
| Delaware State | 9 | at | Delaware | 35 | @ CAAF | |||
| Norfolk State | 7 | at | James Madison | 63 | @ SBC (1A) | |||
| Winston-Salem State | 0 | at | North Carolina Central | 41 | CIAA (D2) | |||
| Howard | 20 | at | South Florida | 42 | @ AAC (1A) | |||
| Morgan State | 21 | at | Towson | 29 | @ CAAF | |||
| 9/17/2022 | Virginia U-Lynchburg | 19 | at | Delaware State | 35 | None (Unk?) | ||
| Morehouse | 0 | vs | Howard | 31 | East Rutherford NJ | vs SIAC (D2) | ||
| Sacred Heart | 9 | at | Morgan State | 24 | NE | |||
| North Carolina Central | 45 | at | New Hampshire | 27 | @ CAAF | |||
| Hampton | 17 | at | Norfolk State | 7 | CAAF | |||
| 9/24/2022 | Merrimack | 26 | at | Delaware State | 13 | NE | ||
| St Francis PA | 45 | at | Norfolk State | 26 | NE | |||
| South Carolina State | 27 | at | North Carolina A&T | 41 | @ BigS | |||
| Virginia U-Lynchburg | 14 | at | North Carolina Central | 59 | None (Unk?) | |||
| 9/29/2022 | South Carolina State | 10 | at | South Carolina | 50 | @ SEC (1A) | ||
| 10/1/2022 | North Carolina Central | 18 | at | Campbell | 48 | @ BigS | ||
| Robert Morris | 9 | at | Delaware State | 14 | BigS | |||
| Virginia U-Lynchburg | 10 | at | Morgan State | 44 | None (Unk?) | |||
| Norfolk State | 14 | at | Sacred Heart | 31 | @ NE | |||
| Howard | 26 | at | Yale | 34 | @ Ivy | |||
| 10/8/2022 | Norfolk State | 24 | at | Morgan State | 21 | |||
| Florida A&M | 20 | at | South Carolina State | 14 | SWAC | |||
| 10/13/2022 | Morgan State | 20 | at | North Carolina Central | 59 | |||
| 10/15/2022 | Harvard | 41 | at | Howard | 25 | Ivy | ||
| Delaware State | 28 | at | Norfolk State | 7 | ||||
| Virginia U-Lynchburg | 0 | at | South Carolina State | 36 | None (Unk?) | |||
| 10/22/2022 | Morgan State | 7 | at | Delaware | 38 | @ CAAF | ||
| Delaware State | 17 | at | Howard | 35 | ||||
| North Carolina Central | 24 | at | South Carolina State | 26 | ||||
| 10/29/2022 | North Carolina Central | 28 | at | Delaware State | 21 | |||
| South Carolina State | 14 | at | Morgan State | 41 | ||||
| Howard | 49 | at | Norfolk State | 21 | ||||
| 11/5/2022 | Norfolk State | 24 | at | North Carolina A&T | 49 | @ BigS | ||
| Howard | 21 | at | North Carolina Central | 50 | ||||
| Delaware State | 27 | at | South Carolina State | 24 | OT | |||
| Morgan State | 22 | at | Stony Brook | 24 | @ CAAF | |||
| 11/12/2022 | Morgan State | 37 | at | Delaware State | 7 | |||
| South Carolina State | 14 | at | Howard | 28 | ||||
| North Carolina Central | 48 | at | Norfolk State | 14 | ||||
| 11/19/2022 | Campbell | 34 | at | Delaware State | 7 | BigS | ||
| Howard | 35 | at | Morgan State | 6 | ||||
| Norfolk State | 42 | at | South Carolina State | 38 | ||||
| North Carolina Central | 22 | at | Tennessee Tech | 20 | @ OVC | |||
| 12/17/2022 | Jackson State | 34 | vs | North Carolina Central | 41 | OT | Atlanta GA | vs SWAC |