| 9/11/2021 | Misericordia | 28 | at | Keystone (0-10) | 7 | at ECFC | ||
| 9/18/2021 | Wilkes (6-4,5-4) | 35 | at | Misericordia | 15 | |||
| 9/25/2021 | Misericordia | 20 | at | Fairleigh Dickinson-Florham (7-4,5-3) | 31 | |||
| 10/2/2021 | Albright (2-8,1-7) | 20 | at | Misericordia | 31 | |||
| 10/9/2021 | Misericordia | 16 | at | Lycoming (8-3,7-2) | 44 | |||
| 10/16/2021 | Misericordia | 0 | at | Stevenson (5-6,5-3) | 37 | |||
| 10/23/2021 | Delaware Valley (11-1,8-0) | 35 | at | Misericordia | 0 | |||
| 10/30/2021 | King's (5-5,4-5) | 17 | at | Misericordia | 24 | |||
| 11/6/2021 | Misericordia | 17 | at | Lebanon Valley (5-5,4-5) | 31 |
| vs Misericordia | vs Other Opponents | Misericordia compared to OOs | |
| Record: | 6-3 | 43-43 | |
| Points Scored: | 28.56 | 23.99 | -4.57 |
| Points Allowed: | 16.78 | 24.23 | -7.45 |
| Margin: | 11.78 | -0.24 | -12.02 |
| Total Points: | 45.34 | 48.22 | -2.88 |