| 9/2/2021 | Trine (6-4) | 52 | at | Manchester | 14 | MIAA | ||
| 9/11/2021 | Alma (5-5) | 47 | at | Manchester | 23 | MIAA | ||
| 9/18/2021 | Manchester | 7 | at | Olivet (7-3) | 59 | at MIAA | ||
| 10/2/2021 | Manchester | 27 | at | Franklin (6-4,4-3) | 24 | OT | ||
| 10/9/2021 | Defiance (1-9,1-6) | 0 | at | Manchester | 22 | |||
| 10/16/2021 | Manchester | 0 | at | Mt St Joseph (6-4,5-2) | 28 | |||
| 10/23/2021 | Rose-Hulman (8-3,7-0) | 57 | at | Manchester | 14 | |||
| 10/30/2021 | Manchester | 0 | at | Hanover (5-5,4-3) | 33 | |||
| 11/6/2021 | Manchester | 7 | at | Bluffton (4-6,3-4) | 31 | |||
| 11/13/2021 | Anderson (1-9,1-6) | 0 | at | Manchester | 3 |
| vs Manchester | vs Other Opponents | Manchester compared to OOs | |
| Record: | 7-3 | 42-49 | |
| Points Scored: | 33.10 | 25.25 | -7.85 |
| Points Allowed: | 11.70 | 26.20 | -14.50 |
| Margin: | 21.40 | -0.95 | -22.35 |
| Total Points: | 44.80 | 51.45 | -6.65 |