| 9/4/2021 | Minnesota-Morris (5-5) | 32 | at | Macalester | 38 | UMWAC | ||
| 9/11/2021 | Macalester | 0 | at | Trinity TX (9-1) | 64 | at SAA | ||
| 9/25/2021 | Macalester | 27 | at | St Olaf (5-5,4-4) | 40 | |||
| 10/2/2021 | Carleton (7-3,5-3) | 24 | at | Macalester | 10 | |||
| 10/9/2021 | Concordia-Moorhead (4-6,3-5) | 34 | at | Macalester | 27 | |||
| 10/16/2021 | Macalester | 29 | at | Augsburg (4-6,4-4) | 37 | |||
| 10/23/2021 | Macalester | 10 | at | Bethel MN (8-3,6-2) | 63 | |||
| 10/30/2021 | Hamline (4-6,2-6) | 13 | at | Macalester | 23 | |||
| 11/6/2021 | Macalester | 28 | at | St Scholastica (0-8,0-8) | 14 | |||
| 11/13/2021 | Carleton (7-3,5-3) | 48 | at | Macalester | 45 |
| vs Macalester | vs Other Opponents | Macalester compared to OOs | |
| Record: | 7-3 | 44-43 | |
| Points Scored: | 36.90 | 28.68 | -8.22 |
| Points Allowed: | 23.70 | 27.87 | -4.17 |
| Margin: | 13.20 | 0.81 | -12.39 |
| Total Points: | 60.60 | 56.55 | 4.05 |