| 9/4/2021 | Randolph-Macon (9-1) | 31 | at | Dickinson | 21 | ODC | ||
| 9/11/2021 | Muhlenberg (11-2,8-1) | 34 | at | Dickinson | 13 | |||
| 9/18/2021 | Gettysburg (1-9,1-8) | 3 | at | Dickinson | 34 | |||
| 9/25/2021 | Dickinson | 14 | at | Susquehanna (9-2,7-2) | 31 | |||
| 10/2/2021 | McDaniel (2-8,2-7) | 6 | at | Dickinson | 24 | |||
| 10/16/2021 | Dickinson | 14 | at | Moravian (3-7,3-6) | 21 | |||
| 10/23/2021 | Franklin & Marshall (6-5,5-4) | 17 | at | Dickinson | 13 | |||
| 10/30/2021 | Dickinson | 27 | at | Juniata (1-9,1-8) | 10 | |||
| 11/6/2021 | Dickinson | 17 | at | Johns Hopkins (10-2,8-1) | 37 | |||
| 11/13/2021 | Ursinus (7-4,6-3) | 20 | at | Dickinson | 27 | OT |
| vs Dickinson | vs Other Opponents | Dickinson compared to OOs | |
| Record: | 6-4 | 53-45 | |
| Points Scored: | 21.00 | 28.66 | 7.66 |
| Points Allowed: | 20.40 | 24.51 | -4.11 |
| Margin: | 0.60 | 4.15 | 3.55 |
| Total Points: | 41.40 | 53.17 | -11.77 |