| 9/4/2021 | Carthage | 7 | at | Wisconsin-Whitewater (13-1) | 46 | at WIAC | ||
| 9/18/2021 | Carthage | 34 | at | Elmhurst (1-9,1-8) | 17 | |||
| 9/25/2021 | Illinois Wesleyan (3-7,3-6) | 35 | at | Carthage | 62 | |||
| 10/2/2021 | Carthage | 63 | at | Millikin (3-7,3-6) | 42 | |||
| 10/9/2021 | North Central (13-1,9-0) | 64 | at | Carthage | 13 | |||
| 10/16/2021 | North Park (2-8,2-7) | 33 | at | Carthage | 30 | |||
| 10/23/2021 | Carthage | 20 | at | Wheaton (10-2,8-1) | 69 | |||
| 10/30/2021 | Augustana IL (5-5,4-5) | 42 | at | Carthage | 14 | |||
| 11/6/2021 | Carthage | 17 | at | Carroll WI (6-4,5-4) | 26 | |||
| 11/13/2021 | Washington U (7-4,7-2) | 37 | at | Carthage | 16 |
| vs Carthage | vs Other Opponents | Carthage compared to OOs | |
| Record: | 7-3 | 56-45 | |
| Points Scored: | 41.10 | 30.18 | -10.92 |
| Points Allowed: | 27.60 | 25.91 | 1.69 |
| Margin: | 13.50 | 4.27 | -9.23 |
| Total Points: | 68.70 | 56.09 | 12.61 |