| 9/4/2021 | Utica (6-5) | 39 | at | Alfred State | 21 | E8 | ||
| 9/11/2021 | Alfred State | 27 | at | Rochester (3-7) | 28 | at LL | ||
| 9/18/2021 | University of New England (4-5) | 20 | at | Alfred State | 17 | CCF | ||
| 9/25/2021 | Alfred State | 35 | at | Defiance (1-9) | 28 | at HCA | ||
| 10/9/2021 | SUNY-Maritime (3-6,3-3) | 20 | at | Alfred State | 35 | |||
| 10/16/2021 | Anna Maria (7-3,5-1) | 28 | at | Alfred State | 17 | |||
| 10/23/2021 | Alfred State | 24 | at | Gallaudet (4-3,3-3) | 21 | |||
| 10/30/2021 | Alfred State | 38 | at | Keystone (0-10,0-6) | 7 | |||
| 11/6/2021 | Castleton State (6-4,4-2) | 24 | at | Alfred State | 35 | |||
| 11/13/2021 | Alfred State | 37 | at | Dean (2-8,1-5) | 15 | |||
| 11/20/2021 | Alfred State | 16 | at | UMass Dartmouth (9-2) | 42 | at MSCAC |
| vs Alfred State | vs Other Opponents | Alfred State compared to OOs | |
| Record: | 5-6 | 40-56 | |
| Points Scored: | 24.73 | 21.22 | -3.51 |
| Points Allowed: | 27.45 | 28.24 | -0.79 |
| Margin: | -2.72 | -7.02 | -4.30 |
| Total Points: | 52.18 | 49.46 | 2.72 |