| 9/4/2021 | West Virginia State (6-5) | 17 | at | Shippensburg | 25 | MtnE | ||
| 9/11/2021 | Shippensburg | 30 | at | Edinboro (4-6,4-6) | 9 | |||
| 9/18/2021 | Shippensburg | 62 | at | Clarion (0-10,0-9) | 33 | |||
| 9/25/2021 | Bloomsburg (3-8,3-7) | 7 | at | Shippensburg | 51 | |||
| 10/2/2021 | Shippensburg | 27 | at | Shepherd (13-2,10-1) | 59 | |||
| 10/9/2021 | West Chester (6-5,6-4) | 18 | at | Shippensburg | 34 | |||
| 10/16/2021 | Shippensburg | 3 | at | Kutztown (11-2,9-2) | 20 | |||
| 10/23/2021 | Millersville (2-9,2-8) | 7 | at | Shippensburg | 38 | |||
| 10/30/2021 | Shippensburg | 24 | at | East Stroudsburg (5-6,4-6) | 23 | |||
| 11/6/2021 | Lock Haven (1-10,0-10) | 14 | at | Shippensburg | 52 | |||
| 11/13/2021 | Mercyhurst (4-7,3-7) | 13 | at | Shippensburg | 17 |
| vs Shippensburg | vs Other Opponents | Shippensburg compared to OOs | |
| Record: | 2-9 | 53-61 | |
| Points Scored: | 20.00 | 23.79 | 3.79 |
| Points Allowed: | 33.00 | 27.73 | 5.27 |
| Margin: | -13.00 | -3.94 | 9.06 |
| Total Points: | 53.00 | 51.52 | 1.48 |