| 9/2/2021 | Northwest Missouri State (11-2,9-1) | 15 | at | Fort Hays State | 7 | | | |
| 9/9/2021 | Fort Hays State | 31 | at | Missouri Western (6-5,5-5) | 38 | | | |
| 9/18/2021 | Lincoln MO (0-10) | 0 | at | Fort Hays State | 72 | | | GLV |
| 9/25/2021 | Fort Hays State | 42 | at | Missouri Southern (3-8,2-8) | 21 | | | |
| 10/2/2021 | Nebraska-Kearney (10-3,8-2) | 35 | at | Fort Hays State | 42 | | | |
| 10/9/2021 | Fort Hays State | 20 | at | Washburn (9-3,8-2) | 23 | | | |
| 10/16/2021 | Central Oklahoma (4-7,3-7) | 24 | at | Fort Hays State | 14 | | | |
| 10/23/2021 | Fort Hays State | 21 | at | Central Missouri (4-7,3-7) | 17 | | | |
| 10/30/2021 | Emporia State (6-6,5-5) | 15 | at | Fort Hays State | 12 | | | |
| 11/6/2021 | Fort Hays State | 64 | at | Northeastern State (2-9,1-9) | 6 | | | |
| 11/13/2021 | Pittsburg State (8-3,7-3) | 34 | at | Fort Hays State | 24 | | | |