| 9/2/2021 | California PA | 23 | at | Fairmont State (5-6) | 14 | at MtnE | ||
| 9/11/2021 | Lock Haven (1-10,0-10) | 0 | at | California PA | 59 | |||
| 9/18/2021 | Millersville (2-9,2-8) | 0 | at | California PA | 30 | |||
| 9/25/2021 | California PA | 20 | at | Edinboro (4-6,4-6) | 12 | |||
| 10/2/2021 | Mercyhurst (4-7,3-7) | 0 | at | California PA | 37 | |||
| 10/9/2021 | California PA | 38 | at | Gannon (5-6,4-6) | 17 | |||
| 10/16/2021 | Clarion (0-10,0-9) | at | California PA | Cancelled | ||||
| 10/23/2021 | California PA | 38 | at | Indiana PA (7-3,7-3) | 34 | |||
| 10/30/2021 | Seton Hill (5-6,4-6) | 14 | at | California PA | 42 | |||
| 11/6/2021 | California PA | 26 | at | Slippery Rock (9-3,8-2) | 38 | |||
| 11/13/2021 | California PA | 24 | at | Bloomsburg (3-8,3-7) | 9 |
| vs California PA | vs Other Opponents | California PA compared to OOs | |
| Record: | 1-9 | 44-65 | |
| Points Scored: | 13.80 | 22.51 | 8.71 |
| Points Allowed: | 33.70 | 28.74 | 4.96 |
| Margin: | -19.90 | -6.23 | 13.67 |
| Total Points: | 47.50 | 51.25 | -3.75 |