| 9/4/2021 | Alderson-Broaddus | 3 | at | Mercyhurst (4-7) | 18 | | | at PSAC |
| 9/11/2021 | West Liberty (4-7,4-6) | 24 | at | Alderson-Broaddus | 0 | | | |
| 9/18/2021 | Alderson-Broaddus | 6 | at | Wheeling (5-6,5-5) | 28 | | | |
| 9/25/2021 | Charleston WV (8-2,8-2) | 69 | at | Alderson-Broaddus | 7 | | | |
| 10/2/2021 | Alderson-Broaddus | 13 | at | West Virginia State (6-5,6-4) | 45 | | | |
| 10/9/2021 | Alderson-Broaddus | 10 | at | Fairmont State (5-6,5-5) | 44 | | | |
| 10/16/2021 | Glenville State (3-7,3-7) | 35 | at | Alderson-Broaddus | 21 | | | |
| 10/23/2021 | Alderson-Broaddus | 49 | at | West Virginia Wesleyan (0-10,0-9) | 20 | | | |
| 10/30/2021 | Frostburg State (10-1,9-1) | 45 | at | Alderson-Broaddus | 7 | | | |
| 11/6/2021 | Concord (4-6,4-6) | 23 | at | Alderson-Broaddus | 10 | | | |
| 11/13/2021 | Alderson-Broaddus | 7 | at | Notre Dame OH (11-2,9-1) | 72 | | | |