| 9/4/2021 | Warner U. (3-8) | 14 | at | Stetson | 54 | MSC (NAIA) | ||
| 9/11/2021 | Ave Maria (5-6) | 16 | at | Stetson | 49 | MSC (NAIA) | ||
| 9/25/2021 | Stetson | 0 | at | Princeton (9-1) | 63 | at Ivy | ||
| 10/2/2021 | Davidson (8-3,7-1) | 35 | at | Stetson | 28 | |||
| 10/9/2021 | Stetson | 3 | at | Marist (5-5,5-3) | 34 | |||
| 10/16/2021 | St Thomas (7-3,6-2) | 38 | at | Stetson | 7 | |||
| 10/23/2021 | Stetson | vs | Drake (2-8,1-6) | Cancelled COVID | ||||
| 10/30/2021 | Stetson | 56 | at | Presbyterian (2-9,0-8) | 14 | |||
| 11/6/2021 | Dayton (6-4,5-3) | 41 | at | Stetson | 13 | |||
| 11/13/2021 | Stetson | 35 | at | Morehead State (7-4,6-2) | 36 | |||
| 11/20/2021 | San Diego (7-4,7-1) | 41 | at | Stetson | 16 |
| vs Stetson | vs Other Opponents | Stetson compared to OOs | |
| Record: | 7-3 | 54-52 | |
| Points Scored: | 33.20 | 27.10 | -6.10 |
| Points Allowed: | 26.10 | 29.78 | -3.68 |
| Margin: | 7.10 | -2.68 | -9.78 |
| Total Points: | 59.30 | 56.88 | 2.42 |