| 9/18/2021 | Pennsylvania | 30 | at | Bucknell (1-10) | 6 | at Pat | ||
| 9/25/2021 | Pennsylvania | 14 | at | Lafayette (3-8) | 24 | at Pat | ||
| 10/1/2021 | Dartmouth (9-1,6-1) | 31 | at | Pennsylvania | 7 | |||
| 10/9/2021 | Lehigh (3-8) | 0 | at | Pennsylvania | 20 | Pat | ||
| 10/16/2021 | Pennsylvania | 14 | at | Columbia (7-3,4-3) | 23 | |||
| 10/23/2021 | Pennsylvania | 28 | at | Yale (5-5,4-3) | 42 | |||
| 10/30/2021 | Brown (2-8,1-6) | 17 | at | Pennsylvania | 45 | |||
| 11/6/2021 | Cornell (2-8,1-6) | 15 | at | Pennsylvania | 12 | |||
| 11/13/2021 | Pennsylvania | 7 | at | Harvard (8-2,5-2) | 23 | |||
| 11/20/2021 | Princeton (9-1,6-1) | 34 | at | Pennsylvania | 14 |
| vs Pennsylvania | vs Other Opponents | Pennsylvania compared to OOs | |
| Record: | 7-3 | 42-51 | |
| Points Scored: | 21.50 | 23.74 | 2.24 |
| Points Allowed: | 19.10 | 26.08 | -6.98 |
| Margin: | 2.40 | -2.34 | -4.74 |
| Total Points: | 40.60 | 49.82 | -9.22 |