| 9/4/2021 | Miles (6-5) | 13 | at | Alabama State | 14 | OT | SIAC (D2) | |
| 9/11/2021 | Alabama State | 0 | at | Auburn (6-7) | 62 | at SEC | ||
| 9/25/2021 | Bethune-Cookman (2-9,2-6) | 24 | at | Alabama State | 38 | |||
| 10/2/2021 | Alabama State | 0 | at | Florida A&M (9-3,7-1) | 28 | |||
| 10/9/2021 | Ark Pine Bluff (2-9,1-7) | 15 | at | Alabama State | 35 | |||
| 10/16/2021 | Alabama State | 7 | at | Jackson State (11-2,9-0) | 28 | |||
| 10/30/2021 | Alabama A&M (7-3,5-3) | 42 | vs | Alabama State | 28 | Birmingham AL | ||
| 11/6/2021 | Alabama State | 20 | at | Prairie View (7-5,6-3) | 24 | |||
| 11/13/2021 | Alabama State | 31 | at | Mississippi Valley State (4-7,3-5) | 44 | |||
| 11/20/2021 | Texas Southern (3-8,2-6) | 21 | at | Alabama State | 24 | |||
| 11/25/2021 | Tuskegee (3-8) | 9 | at | Alabama State | 43 | SIAC (D2) |
| vs Alabama State | vs Other Opponents | Alabama State compared to OOs | |
| Record: | 6-5 | 54-61 | |
| Points Scored: | 28.18 | 26.03 | -2.15 |
| Points Allowed: | 21.82 | 27.82 | -6.00 |
| Margin: | 6.36 | -1.79 | -8.15 |
| Total Points: | 50.00 | 53.85 | -3.85 |