| 9/2/2021 | Boise State | 31 | at | UCF (9-4) | 36 | at AAC | ||
| 9/10/2021 | UTEP (7-6) | 13 | at | Boise State | 54 | CUSA | ||
| 9/18/2021 | Oklahoma State (12-2) | 21 | at | Boise State | 20 | B12 | ||
| 9/25/2021 | Boise State | 27 | at | Utah State (11-3,7-2) | 3 | |||
| 10/2/2021 | Nevada (8-5,5-3) | 41 | at | Boise State | 31 | |||
| 10/9/2021 | Boise State | 26 | at | BYU (10-3) | 17 | at Ind | ||
| 10/16/2021 | Air Force (10-3,6-2) | 24 | at | Boise State | 17 | |||
| 10/30/2021 | Boise State | 28 | at | Colorado State (3-9,2-6) | 19 | |||
| 11/6/2021 | Boise State | 40 | at | Fresno State (10-3,6-2) | 14 | |||
| 11/12/2021 | Wyoming (7-6,2-6) | 13 | at | Boise State | 23 | |||
| 11/20/2021 | New Mexico (3-9,1-7) | 0 | at | Boise State | 37 | |||
| 11/26/2021 | Boise State | 16 | vs | San Diego State (12-2,7-2) | 27 | Carson CA |
| vs Boise State | vs Other Opponents | Boise State compared to OOs | |
| Record: | 5-7 | 97-48 | |
| Points Scored: | 19.00 | 29.50 | 10.50 |
| Points Allowed: | 29.17 | 23.09 | 6.08 |
| Margin: | -10.17 | 6.41 | 16.58 |
| Total Points: | 48.17 | 52.59 | -4.42 |