| 9/7/2019 | Defiance | 6 | at | Albion (8-2) | 56 | at MIAA | ||
| 9/14/2019 | Defiance | 6 | at | Hope (9-2) | 80 | at MIAA | ||
| 9/19/2019 | Manchester (4-6,4-4) | 52 | at | Defiance | 21 | |||
| 9/28/2019 | Defiance | 29 | at | Anderson (3-7,1-7) | 56 | |||
| 10/5/2019 | Defiance | 6 | at | Mt St Joseph (7-3,6-2) | 59 | |||
| 10/12/2019 | Hanover (9-2,7-0) | 42 | at | Defiance | 0 | |||
| 10/26/2019 | Defiance | 0 | at | Franklin (5-5,5-3) | 28 | |||
| 11/2/2019 | Defiance | 6 | at | Rose-Hulman (6-4,5-2) | 53 | |||
| 11/9/2019 | Manchester (4-6,4-4) | 19 | at | Defiance | 0 | |||
| 11/16/2019 | Bluffton (2-8,2-6) | 7 | at | Defiance | 10 |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 9-1 | 46-44 | |
| Points Scored: | 45.20 | 30.64 | -14.56 |
| Points Allowed: | 8.40 | 29.68 | -21.28 |
| Margin: | 36.80 | 0.96 | -35.84 |
| Total Points: | 53.60 | 60.32 | -6.72 |