| 9/5/2015 | Defiance | 13 | at | Adrian (7-3) | 31 | at MIAA | ||
| 9/12/2015 | Defiance | 8 | at | Centre (8-2) | 25 | at SAA | ||
| 9/19/2015 | Defiance | 20 | at | Mt St Joseph (7-3,6-2) | 38 | |||
| 9/26/2015 | Hanover (2-8,2-6) | 14 | at | Defiance | 19 | |||
| 10/10/2015 | Manchester (5-4,5-3) | 42 | at | Defiance | 21 | |||
| 10/17/2015 | Defiance | 7 | at | Rose-Hulman (8-2,6-2) | 42 | |||
| 10/24/2015 | Earlham (0-10,0-8) | 7 | at | Defiance | 51 | |||
| 10/31/2015 | Defiance | 13 | at | Anderson (2-8,2-6) | 17 | |||
| 11/7/2015 | Defiance | 7 | at | Franklin (8-3,8-0) | 35 | |||
| 11/14/2015 | Bluffton (6-4,5-3) | 35 | at | Defiance | 14 |
| vs Defiance | vs Other Opponents | Defiance compared to OOs | |
| Record: | 8-2 | 45-45 | |
| Points Scored: | 28.60 | 30.91 | 2.31 |
| Points Allowed: | 17.30 | 32.16 | -14.86 |
| Margin: | 11.30 | -1.25 | -12.55 |
| Total Points: | 45.90 | 63.07 | -17.17 |